TY - JOUR
T1 - The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)
AU - Ibanez, Agustin
AU - Cetkovich, Marcelo
AU - Petroni, Agustin
AU - Urquina, Hugo
AU - Baez, Sandra
AU - Gonzalez-Gadea, Maria Luz
AU - Kamienkowski, Juan Esteban
AU - Torralva, Teresa
AU - Torrente, Fernando
AU - Strejilevich, Sergio
AU - Teitelbaum, Julia
AU - Hurtado, Esteban
AU - Guex, Raphael
AU - Melloni, Margherita
AU - Lischinsky, Alicia
AU - Sigman, Mariano
AU - Manes, Facundo
N1 - Funding Information:
Some of authors received funding from Foundation Instituto de Neurología Cognitiva and Consejo Nacional de Investigaciones Científicas y Técnicas, this does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.
PY - 2012/5/18
Y1 - 2012/5/18
N2 - Background: Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making. Nevertheless, no previous report has assessed a decision-making task that includes the examination of the neural correlates of reward and gambling in adults with ADHD and those with BD. Methodology/Principal Findings: We used the Iowa gambling task (IGT), a task of rational decision-making under risk (RDMUR) and a rapid-decision gambling task (RDGT) which elicits behavioral measures as well as event-related potentials (ERPs: fERN and P3) in connection to the motivational impact of events. We did not observe between-group differences for decision-making under risk or ambiguity (RDMUR and IGT); however, there were significant differences for the ERP-assessed RDGT. Compared to controls, the ADHD group showed a pattern of impaired learning by feedback (fERN) and insensitivity to reward magnitude (P3). This ERP pattern (fERN and P3) was associated with impulsivity, hyperactivity, executive function and working memory. Compared to controls, the BD group showed fERN- and P3-enhanced responses to reward magnitude regardless of valence. This ERP pattern (fERN and P3) was associated with mood and inhibitory control. Consistent with the ERP findings, an analysis of source location revealed reduced responses of the cingulate cortex to the valence and magnitude of rewards in patients with ADHD and BD. Conclusions/Significance: Our data suggest that neurophysiological (ERPs) paradigms such as the RDGT are well suited to assess subclinical decision-making processes in patients with ADHD and BD as well as for linking the cingulate cortex with action monitoring systems.
AB - Background: Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making. Nevertheless, no previous report has assessed a decision-making task that includes the examination of the neural correlates of reward and gambling in adults with ADHD and those with BD. Methodology/Principal Findings: We used the Iowa gambling task (IGT), a task of rational decision-making under risk (RDMUR) and a rapid-decision gambling task (RDGT) which elicits behavioral measures as well as event-related potentials (ERPs: fERN and P3) in connection to the motivational impact of events. We did not observe between-group differences for decision-making under risk or ambiguity (RDMUR and IGT); however, there were significant differences for the ERP-assessed RDGT. Compared to controls, the ADHD group showed a pattern of impaired learning by feedback (fERN) and insensitivity to reward magnitude (P3). This ERP pattern (fERN and P3) was associated with impulsivity, hyperactivity, executive function and working memory. Compared to controls, the BD group showed fERN- and P3-enhanced responses to reward magnitude regardless of valence. This ERP pattern (fERN and P3) was associated with mood and inhibitory control. Consistent with the ERP findings, an analysis of source location revealed reduced responses of the cingulate cortex to the valence and magnitude of rewards in patients with ADHD and BD. Conclusions/Significance: Our data suggest that neurophysiological (ERPs) paradigms such as the RDGT are well suited to assess subclinical decision-making processes in patients with ADHD and BD as well as for linking the cingulate cortex with action monitoring systems.
UR - http://www.scopus.com/inward/record.url?scp=84862075859&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0037306
DO - 10.1371/journal.pone.0037306
M3 - Article
C2 - 22624011
AN - SCOPUS:84862075859
SN - 1932-6203
VL - 7
JO - PLoS ONE
JF - PLoS ONE
IS - 5
M1 - e37306
ER -