TY - JOUR
T1 - The genetic architecture of the human cerebral cortex
AU - Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group
AU - Grasby, Katrina L.
AU - Jahanshad, Neda
AU - Painter, Jodie N.
AU - Colodro-Conde, Lucía
AU - Bralten, Janita
AU - Hibar, Derrek P.
AU - Lind, Penelope A.
AU - Pizzagalli, Fabrizio
AU - Ching, Christopher R.K.
AU - McMahon, Mary Agnes B.
AU - Shatokhina, Natalia
AU - Zsembik, Leo C.P.
AU - Thomopoulos, Sophia I.
AU - Zhu, Alyssa H.
AU - Strike, Lachlan T.
AU - Agartz, Ingrid
AU - Alhusaini, Saud
AU - Almeida, Marcio A.A.
AU - Alnæs, Dag
AU - Amlien, Inge K.
AU - Andersson, Micael
AU - Ard, Tyler
AU - Armstrong, Nicola J.
AU - Ashley-Koch, Allison
AU - Atkins, Joshua R.
AU - Bernard, Manon
AU - Brouwer, Rachel M.
AU - Buimer, Elizabeth E.L.
AU - Bülow, Robin
AU - Bürger, Christian
AU - Cannon, Dara M.
AU - Chakravarty, Mallar
AU - Chen, Qiang
AU - Cheung, Joshua W.
AU - Couvy-Duchesne, Baptiste
AU - Dale, Anders M.
AU - Dalvie, Shareefa
AU - de Araujo, Tânia K.
AU - de Zubicaray, Greig I.
AU - de Zwarte, Sonja M.C.
AU - den Braber, Anouk
AU - Doan, Nhat Trung
AU - Dohm, Katharina
AU - Ehrlich, Stefan
AU - Engelbrecht, Hannah Ruth
AU - Erk, Susanne
AU - Fan, Chun Chieh
AU - Fedko, Iryna O.
AU - Foley, Sonya F.
AU - Adams, Hieab H.H.
N1 - Publisher Copyright:
© 2020 American Association for the Advancement of Science. All rights reserved.
PY - 2020/3/20
Y1 - 2020/3/20
N2 - The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
AB - The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
UR - http://www.scopus.com/inward/record.url?scp=85082081461&partnerID=8YFLogxK
U2 - 10.1126/science.aay6690
DO - 10.1126/science.aay6690
M3 - Article
C2 - 32193296
AN - SCOPUS:85082081461
SN - 0036-8075
VL - 367
JO - Science
JF - Science
IS - 6484
M1 - aay6690
ER -
