TY - JOUR
T1 - Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula
AU - García-Cordero, Indira
AU - Sedeño, Lucas
AU - Fraiman, Daniel
AU - Craiem, Damian
AU - De La Fuente, Laura Alethia
AU - Salamone, Paula
AU - Serrano, Cecilia
AU - Sposato, Luciano
AU - Manes, Facundo
AU - Ibañez, Agustín
N1 - Publisher Copyright:
© 2015 American Heart Association, Inc.
PY - 2015/9/28
Y1 - 2015/9/28
N2 - Background and Purpose - Stroke and neurodegeneration cause significant brain damage and cognitive impairment, especially if the insular cortex is compromised. This study explores for the first time whether these 2 causes differentially alter connectivity patterns in the insular cortex. Methods - Resting state-functional magnetic resonance imaging data were collected from patients with insular stroke, patients with behavioral variant frontotemporal dementia, and healthy controls. Data from the 3 groups were assessed through a correlation function analysis. Specifically, we compared decreases in connectivity as a function of voxel Euclidean distance within the insular cortex. Results - Relative to controls, patients with stroke showed faster connectivity decays as a function of distance (hypoconnectivity). In contrast, the behavioral variant frontotemporal dementia group exhibited significant hyperconnectivity between neighboring voxels. Both patient groups evinced global hypoconnectivity. No between-group differences were observed in a volumetrically and functionally comparable region without ischemia or neurodegeneration. Conclusions - Functional insular cortex connectivity is affected differently by cerebral ischemia and neurodegeneration, possibly because of differences in the cause-specific pathophysiological mechanisms of each disease. These findings have important clinical and theoretical implications.
AB - Background and Purpose - Stroke and neurodegeneration cause significant brain damage and cognitive impairment, especially if the insular cortex is compromised. This study explores for the first time whether these 2 causes differentially alter connectivity patterns in the insular cortex. Methods - Resting state-functional magnetic resonance imaging data were collected from patients with insular stroke, patients with behavioral variant frontotemporal dementia, and healthy controls. Data from the 3 groups were assessed through a correlation function analysis. Specifically, we compared decreases in connectivity as a function of voxel Euclidean distance within the insular cortex. Results - Relative to controls, patients with stroke showed faster connectivity decays as a function of distance (hypoconnectivity). In contrast, the behavioral variant frontotemporal dementia group exhibited significant hyperconnectivity between neighboring voxels. Both patient groups evinced global hypoconnectivity. No between-group differences were observed in a volumetrically and functionally comparable region without ischemia or neurodegeneration. Conclusions - Functional insular cortex connectivity is affected differently by cerebral ischemia and neurodegeneration, possibly because of differences in the cause-specific pathophysiological mechanisms of each disease. These findings have important clinical and theoretical implications.
KW - cerebral cortex
KW - dementia
KW - magnetic resonance imaging
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=84940426248&partnerID=8YFLogxK
U2 - 10.1161/STROKEAHA.115.009598
DO - 10.1161/STROKEAHA.115.009598
M3 - Article
C2 - 26185182
AN - SCOPUS:84940426248
SN - 0039-2499
VL - 46
SP - 2673
EP - 2677
JO - Stroke
JF - Stroke
IS - 9
ER -