Prevalence of anti-SARS-CoV-2 antibody in hemodialysis facilities: a cross-sectional multicenter study from Madinah

Abdulrahman A. Housawi, Shazada Junaid S. Qazi, Abdulhalem A. Jan, Rashid A. Osman, Mashil M. Alshamrani, Talal A. AlFaadhel, Fayez F. AlHejaili, Jaffar A. Al-Tawfiq, Ahmed A. Wafa, Abdulmageed E. Hamza, Moustafa A. Hassan, Suliman A. Alharbi, Hamza Albasheer, Majed M. Almohmmdi, Salem A. Alsisi, Michal Mankowski, Joris Van de Klundert, Amal M. Alhelal, Fatima H. Sala, Ali KheyamiBader A. Alhomayeed

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BACKGROUND: Since the occurrence of coronavirus disease in 2019 (COVID-19), the global community has witnessed its exponential spread with devastating outcomes within the general population and specifically within hemodialysis patients. OBJECTIVES: Compare the state of immunity to SARS-CoV-2 among hemodialysis patients and staff. DESIGN: Cross-sectional study with a prospective follow-up period. SETTING: Hemodialysis centers in Madinah region. PATIENTS AND METHODS: We prospectively tested for SARS-CoV-2 antibodies in dialysis patients using dialysis centers staff as controls. The participants were tested on four occasions when feasible for the presence of anti-SARS-CoV-2 antibodies. We also analyzed factors that might be associated with seropositivity. MAIN OUTCOME MEASURES: SARS-CoV-2 positivity using immuno-globulin G (IgG) levels SAMPLE SIZE: 830 participants, 677 patients and 153 dialysis centers staff as controls. RESULTS: Of the total participants, 325 (257 patients and 68 staff) were positive for SARS-CoV-2 IgG antibodies, for a prevalence of 38.0% and 44.4% among patients and staff, respectively (P=.1379). Participants with a history of COVID-19 or related symptoms were more likely to have positive IgG (P<.0001). Surprisingly, positivity was also center-dependent. In a multivariable logistic regression, a history of infection and related symptoms contributed significantly to developing immunity. CONCLUSION: The high prevalence of SARS-CoV-2 antibody among hemodialysis patients and previously asymptomatic staff suggested past asymptomatic infection. Some centers showed more immunity effects than others.

Idioma originalInglés
Páginas (desde-hasta)229-235
Número de páginas7
PublicaciónAnnals of Saudi Medicine
EstadoPublicada - jul. 2022
Publicado de forma externa


Profundice en los temas de investigación de 'Prevalence of anti-SARS-CoV-2 antibody in hemodialysis facilities: a cross-sectional multicenter study from Madinah'. En conjunto forman una huella única.

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