Osteochondroma after Hematopoietic Stem Cell Transplantation in Childhood. An Italian Study on Behalf of the AIEOP-HSCT Group

Maura Faraci; Francesca Bagnasco; Paola Corti; Chiara Messina; Franca Fagioli; Marta Podda; Arcangelo Prete; Desirè Caselli; Edoardo Lanino; Giorgio Dini; Roberto Rondelli; Riccardo Haupt

doi:10.1016/j.bbmt.2009.06.003

Osteochondroma after Hematopoietic Stem Cell Transplantation in Childhood. An Italian Study on Behalf of the AIEOP-HSCT Group

Maura Faraci
, Francesca Bagnasco
, Paola Corti
, Chiara Messina
, Franca Fagioli
, Marta Podda
, Arcangelo Prete
, Desirè Caselli
, Edoardo Lanino
, Giorgio Dini
, Roberto Rondelli
, Riccardo Haupt

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

16 Citas (Scopus)

Resumen

A retrospective study was conducted among Italian children treated with hematopoietic stem cell transplant (HSCT) to evaluate the incidence and risk factors in the development of osteochondroma (OC). OC occurred in 27 patients who received autologous or allogeneic HSCT. The estimated 5-, 10-, and 15-year cumulative risk of developing OC was 0.5%, 3.2%, and 6.1%, respectively. Analysis of cumulative risk stratified by the various risk factors revealed that male sex (P = .026), autologous HSCT (P = .001), age at HSCT (≤3 years) (P < .0001), and total body irradiation (TBI) (P < .0001) significantly affected the risk of OC. Multivariate analysis, restricted only to tumor types with at least 1 case of OC, showed that earlier age at HSCT (P = .0004) and TBI (P < .0001) were the only factors that were significantly associated with OC.

Idioma original	Inglés
Páginas (desde-hasta)	1271-1276
Número de páginas	6
Publicación	Biology of Blood and Marrow Transplantation
Volumen	15
N.º	10
DOI	https://doi.org/10.1016/j.bbmt.2009.06.003
Estado	Publicada - oct 2009
Publicado de forma externa	Sí

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Faraci, M., Bagnasco, F., Corti, P., Messina, C., Fagioli, F., Podda, M., Prete, A., Caselli, D., Lanino, E., Dini, G., Rondelli, R., & Haupt, R. (2009). Osteochondroma after Hematopoietic Stem Cell Transplantation in Childhood. An Italian Study on Behalf of the AIEOP-HSCT Group. Biology of Blood and Marrow Transplantation, 15(10), 1271-1276. https://doi.org/10.1016/j.bbmt.2009.06.003

@article{86712ef6dd414adbb6e16afac674c5c2,

title = "Osteochondroma after Hematopoietic Stem Cell Transplantation in Childhood. An Italian Study on Behalf of the AIEOP-HSCT Group",

abstract = "A retrospective study was conducted among Italian children treated with hematopoietic stem cell transplant (HSCT) to evaluate the incidence and risk factors in the development of osteochondroma (OC). OC occurred in 27 patients who received autologous or allogeneic HSCT. The estimated 5-, 10-, and 15-year cumulative risk of developing OC was 0.5\%, 3.2\%, and 6.1\%, respectively. Analysis of cumulative risk stratified by the various risk factors revealed that male sex (P = .026), autologous HSCT (P = .001), age at HSCT (≤3 years) (P < .0001), and total body irradiation (TBI) (P < .0001) significantly affected the risk of OC. Multivariate analysis, restricted only to tumor types with at least 1 case of OC, showed that earlier age at HSCT (P = .0004) and TBI (P < .0001) were the only factors that were significantly associated with OC.",

keywords = "Autologous HSCT, Osteochondroma, Total-body irradiation, Younger age",

author = "Maura Faraci and Francesca Bagnasco and Paola Corti and Chiara Messina and Franca Fagioli and Marta Podda and Arcangelo Prete and Desir{\`e} Caselli and Edoardo Lanino and Giorgio Dini and Roberto Rondelli and Riccardo Haupt",

year = "2009",

month = oct,

doi = "10.1016/j.bbmt.2009.06.003",

language = "English",

volume = "15",

pages = "1271--1276",

journal = "Biology of Blood and Marrow Transplantation",

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}

Faraci, M, Bagnasco, F, Corti, P, Messina, C, Fagioli, F, Podda, M, Prete, A, Caselli, D, Lanino, E, Dini, G, Rondelli, R & Haupt, R 2009, 'Osteochondroma after Hematopoietic Stem Cell Transplantation in Childhood. An Italian Study on Behalf of the AIEOP-HSCT Group', Biology of Blood and Marrow Transplantation, vol. 15, n.º 10, pp. 1271-1276. https://doi.org/10.1016/j.bbmt.2009.06.003

TY - JOUR

T1 - Osteochondroma after Hematopoietic Stem Cell Transplantation in Childhood. An Italian Study on Behalf of the AIEOP-HSCT Group

AU - Faraci, Maura

AU - Bagnasco, Francesca

AU - Corti, Paola

AU - Messina, Chiara

AU - Fagioli, Franca

AU - Podda, Marta

AU - Prete, Arcangelo

AU - Caselli, Desirè

AU - Lanino, Edoardo

AU - Dini, Giorgio

AU - Rondelli, Roberto

AU - Haupt, Riccardo

PY - 2009/10

Y1 - 2009/10

N2 - A retrospective study was conducted among Italian children treated with hematopoietic stem cell transplant (HSCT) to evaluate the incidence and risk factors in the development of osteochondroma (OC). OC occurred in 27 patients who received autologous or allogeneic HSCT. The estimated 5-, 10-, and 15-year cumulative risk of developing OC was 0.5%, 3.2%, and 6.1%, respectively. Analysis of cumulative risk stratified by the various risk factors revealed that male sex (P = .026), autologous HSCT (P = .001), age at HSCT (≤3 years) (P < .0001), and total body irradiation (TBI) (P < .0001) significantly affected the risk of OC. Multivariate analysis, restricted only to tumor types with at least 1 case of OC, showed that earlier age at HSCT (P = .0004) and TBI (P < .0001) were the only factors that were significantly associated with OC.

AB - A retrospective study was conducted among Italian children treated with hematopoietic stem cell transplant (HSCT) to evaluate the incidence and risk factors in the development of osteochondroma (OC). OC occurred in 27 patients who received autologous or allogeneic HSCT. The estimated 5-, 10-, and 15-year cumulative risk of developing OC was 0.5%, 3.2%, and 6.1%, respectively. Analysis of cumulative risk stratified by the various risk factors revealed that male sex (P = .026), autologous HSCT (P = .001), age at HSCT (≤3 years) (P < .0001), and total body irradiation (TBI) (P < .0001) significantly affected the risk of OC. Multivariate analysis, restricted only to tumor types with at least 1 case of OC, showed that earlier age at HSCT (P = .0004) and TBI (P < .0001) were the only factors that were significantly associated with OC.

KW - Autologous HSCT

KW - Osteochondroma

KW - Total-body irradiation

KW - Younger age

UR - https://www.scopus.com/pages/publications/69749114720

U2 - 10.1016/j.bbmt.2009.06.003

DO - 10.1016/j.bbmt.2009.06.003

M3 - Article

C2 - 19747635

AN - SCOPUS:69749114720

SN - 1083-8791

VL - 15

SP - 1271

EP - 1276

JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

IS - 10

ER -

Osteochondroma after Hematopoietic Stem Cell Transplantation in Childhood. An Italian Study on Behalf of the AIEOP-HSCT Group

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