TY - JOUR
T1 - Medical and surgical treatments for obesity have opposite effects on peptide YY and appetite
T2 - A prospective study controlled for weight loss
AU - Valderas, Juan P.
AU - Irribarra, Verónica
AU - Boza, Camilo
AU - De La Cruz, Rolando
AU - Liberona, Yessica
AU - Acosta, Ana Maria
AU - Yolito, Macarena
AU - Maiz, Alberto
N1 - Funding Information:
This work was supported by grants from the Department of Nutrition, Diabetes, and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile.
PY - 2010/3
Y1 - 2010/3
N2 - Context: The effects of medical and surgical treatments for obesity on peptide YY (PYY) levels, in patients with similar weight loss, remain unclear. Objective: The objective of the study was to assess PYY and appetite before and after Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), and medical treatment (MED). Design: This was a prospective, controlled, nonrandomized study. Setting: The study was conducted at the Departments of Nutrition and Digestive Surgery at a university hospital. Participants: Participants included three groups of eight patients with similar body mass indexes (RYGB 37.8 ± 0.8, SG 35.3 ± 0.7, and MED 39.1 ± 1.7 kg/m2, P = NS) and eight lean controls (body mass index 21.7 ± 0.7 kg/m 2). Main Outcome Measures: Total plasma PYY, hunger, and satiety visual analog scales in fasting and after ingestion of a standard test meal were measured. Results: At baseline there were no differences in the area under the curve (AUC) of PYY, hunger, or satiety in obese groups. Two months after the interventions, RYGB, SG, and MED groups achieved similar weight loss (17.7 ± 3, 14.9 ± 2.4, 16.6 ± 4%, respectively, P = NS). PYY AUC increased in RYGB (P < 0.001) and SG (P < 0.05) and did not change in MED. PYY levels decreased at fasting, 30 min, and 180 min after a standard test meal in MED(P<0.05). Hunger AUC decreased in RYGB (P < 0.05). Satiety AUC increased in RYGB (P < 0.05) and SG (P < 0.05). Appetite did not change in MED. PYY AUC correlated with satiety AUC (r = 0.35, P < 0.05). Conclusion: RYGB and SG increased PYY and reduced appetite. MED failed to produce changes. Different effects occur despite similar weight loss. This suggests that the weight-loss effects of these procedures are enhanced by an increase in PYY and satiety.
AB - Context: The effects of medical and surgical treatments for obesity on peptide YY (PYY) levels, in patients with similar weight loss, remain unclear. Objective: The objective of the study was to assess PYY and appetite before and after Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), and medical treatment (MED). Design: This was a prospective, controlled, nonrandomized study. Setting: The study was conducted at the Departments of Nutrition and Digestive Surgery at a university hospital. Participants: Participants included three groups of eight patients with similar body mass indexes (RYGB 37.8 ± 0.8, SG 35.3 ± 0.7, and MED 39.1 ± 1.7 kg/m2, P = NS) and eight lean controls (body mass index 21.7 ± 0.7 kg/m 2). Main Outcome Measures: Total plasma PYY, hunger, and satiety visual analog scales in fasting and after ingestion of a standard test meal were measured. Results: At baseline there were no differences in the area under the curve (AUC) of PYY, hunger, or satiety in obese groups. Two months after the interventions, RYGB, SG, and MED groups achieved similar weight loss (17.7 ± 3, 14.9 ± 2.4, 16.6 ± 4%, respectively, P = NS). PYY AUC increased in RYGB (P < 0.001) and SG (P < 0.05) and did not change in MED. PYY levels decreased at fasting, 30 min, and 180 min after a standard test meal in MED(P<0.05). Hunger AUC decreased in RYGB (P < 0.05). Satiety AUC increased in RYGB (P < 0.05) and SG (P < 0.05). Appetite did not change in MED. PYY AUC correlated with satiety AUC (r = 0.35, P < 0.05). Conclusion: RYGB and SG increased PYY and reduced appetite. MED failed to produce changes. Different effects occur despite similar weight loss. This suggests that the weight-loss effects of these procedures are enhanced by an increase in PYY and satiety.
UR - http://www.scopus.com/inward/record.url?scp=77749234172&partnerID=8YFLogxK
U2 - 10.1210/jc.2009-0983
DO - 10.1210/jc.2009-0983
M3 - Article
AN - SCOPUS:77749234172
SN - 0021-972X
VL - 95
SP - 1069
EP - 1075
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 3
ER -