TY - JOUR
T1 - Mapping the neurovascular landscape in aging and dementia
T2 - cerebral small vessel disease markers in a multicenter Latin American cohort
AU - Altschuler, Florencia
AU - Castro-Laguardia, Ana Maria
AU - Canziani, Verónica
AU - O'Byrne, Daniel Franco
AU - Hazelton, Jessica
AU - Migeot, Joaquín
AU - Maito, Marcelo
AU - García, Adolfo M.
AU - Bruno, Martín A.
AU - Magrath, Nahuel
AU - Slachevsky, Andrea
AU - Behrens, María Isabel
AU - Custodio, Nilton
AU - Ávila-Funes, José Alberto
AU - Matallana, Diana
AU - Aguillón, David
AU - Santamaria-García, Hernando
AU - Resende, Elisa
AU - Takada, Leonel
AU - Brusco, Luis Ignacio
AU - Yokoyama, Jennifer S.
AU - Miller, Bruce
AU - Ibáñez, Agustín
AU - Medel, Vicente
AU - Campo, Cecilia Gonzalez
N1 - Publisher Copyright:
© 2026 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2026/5
Y1 - 2026/5
N2 - INTRODUCTION: Cerebral small vessel disease (CSVD) is a key contributor to cognitive impairment and dementia, yet few studies have compared CSVD across dementia variants, particularly in underrepresented populations. METHODS: In a multicenter cross-sectional study, we analyzed magnetic resonance imaging (MRI) markers of CSVD, including white matter hyperintensities (WMHs), lacunes, and cerebral microbleeds, along with cardiometabolic risk factors and cognitive performance using regression models in 1675 participants (790 healthy controls, 642 with Alzheimer's disease [AD], and 243 with frontotemporal dementia [FTD]) from six Latin American countries. RESULTS: AD showed the greatest CSVD burden, whereas FTD exhibited an intermediate profile driven by elevated WMHs. Blood pressure and smoking were the strongest correlates of WMHs, while diabetes was associated with microbleeds. WMH burden was linked to global and domain-specific cognitive impairment. DISCUSSION: This first large-cohort Latin American study identifies WMHs as a key vascular substrate of cognitive impairment, with AD showing the greatest CSVD burden.
AB - INTRODUCTION: Cerebral small vessel disease (CSVD) is a key contributor to cognitive impairment and dementia, yet few studies have compared CSVD across dementia variants, particularly in underrepresented populations. METHODS: In a multicenter cross-sectional study, we analyzed magnetic resonance imaging (MRI) markers of CSVD, including white matter hyperintensities (WMHs), lacunes, and cerebral microbleeds, along with cardiometabolic risk factors and cognitive performance using regression models in 1675 participants (790 healthy controls, 642 with Alzheimer's disease [AD], and 243 with frontotemporal dementia [FTD]) from six Latin American countries. RESULTS: AD showed the greatest CSVD burden, whereas FTD exhibited an intermediate profile driven by elevated WMHs. Blood pressure and smoking were the strongest correlates of WMHs, while diabetes was associated with microbleeds. WMH burden was linked to global and domain-specific cognitive impairment. DISCUSSION: This first large-cohort Latin American study identifies WMHs as a key vascular substrate of cognitive impairment, with AD showing the greatest CSVD burden.
KW - Alzheimer's disease
KW - Latin America
KW - cardiometabolic risk factors
KW - cerebral small vessel disease
KW - dementia
KW - frontotemporal dementia
UR - https://www.scopus.com/pages/publications/105040199247
U2 - 10.1002/alz.71468
DO - 10.1002/alz.71468
M3 - Article
C2 - 42192214
AN - SCOPUS:105040199247
SN - 1552-5260
VL - 22
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 5
M1 - e71468
ER -
ODS 3: Salud y bienestar