Inference of threshold network models of the tryptophan operon in Escherichia coli

Producción científica: Capítulo del libro/informe/acta de congresoContribución a la conferenciarevisión exhaustiva

Resumen

A recent Boolean model of the tryptophan operon in Escherichia coli has been introduced, which exhibits a desired set of fixed points modeling the operon state being on or off. Nevertheless, when updated synchronously, the model also reveals spurious limit cycles with a larger basin of attraction than the desired fixed points. This paper presents the search via evolutionary computation for threshold network models that exhibit the desired fixed points without any limit cycles. The proposed framework was applied using differential evolution and particle swarm optimization, the latter being the most efficient and effective method based on the results obtained by the simulations. Particle swarm optimization found two correct threshold networks, one of which has only weight values -1,0,1, making the model more interpretable.

Idioma originalInglés
Título de la publicación alojadaCIBCB 2023 - 20th IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology
EditorialInstitute of Electrical and Electronics Engineers Inc.
ISBN (versión digital)9798350310177
DOI
EstadoPublicada - 2023
Publicado de forma externa
Evento20th IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB 2023 - Eindhoven, Países Bajos
Duración: 29 ago. 202331 ago. 2023

Serie de la publicación

NombreCIBCB 2023 - 20th IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology

Conferencia

Conferencia20th IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB 2023
País/TerritorioPaíses Bajos
CiudadEindhoven
Período29/08/2331/08/23

Huella

Profundice en los temas de investigación de 'Inference of threshold network models of the tryptophan operon in Escherichia coli'. En conjunto forman una huella única.

Citar esto