TY - JOUR
T1 - Impairments in negative emotion recognition and empathy for pain in Huntington's disease families
AU - Baez, Sandra
AU - Herrera, Eduar
AU - Gershanik, Oscar
AU - Garcia, Adolfo M.
AU - Bocanegra, Yamile
AU - Kargieman, Lucila
AU - Manes, Facundo
AU - Ibanez, Agustin
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Lack of empathy and emotional disturbances are prominent clinical features of Huntington's disease (HD). While emotion recognition impairments in HD patients are well established, there are no experimental designs assessing empathy in this population. The present study seeks to cover such a gap in the literature. Eighteen manifest HD patients, 19 first-degree asymptomatic relatives, and 36 healthy control participants completed two emotion-recognition tasks with different levels of contextual dependence. They were also evaluated with an empathy-for-pain task tapping the perception of intentional and accidental harm. Moreover, we explored potential associations among empathy, emotion recognition, and other relevant factors - e.g., executive functions (EF). The results showed that both HD patients and asymptomatic relatives are impaired in the recognition of negative emotions from isolated faces. However, their performance in emotion recognition was normal in the presence of contextual cues. HD patients also showed subtle empathy impairments. There were no significant correlations between EF, empathy, and emotion recognition measures in either HD patients or relatives. In controls, EF was positively correlated with emotion recognition. Furthermore, emotion recognition was positively correlated with the performance in the empathy task. Our findings highlight the preserved cognitive abilities in HD families when using more ecological tasks displaying emotional expressions in the context in which they typically appear. Moreover, our results suggest that emotion recognition impairments may constitute a potential biomarker of HD onset and progression. These results contribute to the understanding of emotion recognition and empathy deficits observed in HD and have important theoretical and clinical implications.
AB - Lack of empathy and emotional disturbances are prominent clinical features of Huntington's disease (HD). While emotion recognition impairments in HD patients are well established, there are no experimental designs assessing empathy in this population. The present study seeks to cover such a gap in the literature. Eighteen manifest HD patients, 19 first-degree asymptomatic relatives, and 36 healthy control participants completed two emotion-recognition tasks with different levels of contextual dependence. They were also evaluated with an empathy-for-pain task tapping the perception of intentional and accidental harm. Moreover, we explored potential associations among empathy, emotion recognition, and other relevant factors - e.g., executive functions (EF). The results showed that both HD patients and asymptomatic relatives are impaired in the recognition of negative emotions from isolated faces. However, their performance in emotion recognition was normal in the presence of contextual cues. HD patients also showed subtle empathy impairments. There were no significant correlations between EF, empathy, and emotion recognition measures in either HD patients or relatives. In controls, EF was positively correlated with emotion recognition. Furthermore, emotion recognition was positively correlated with the performance in the empathy task. Our findings highlight the preserved cognitive abilities in HD families when using more ecological tasks displaying emotional expressions in the context in which they typically appear. Moreover, our results suggest that emotion recognition impairments may constitute a potential biomarker of HD onset and progression. These results contribute to the understanding of emotion recognition and empathy deficits observed in HD and have important theoretical and clinical implications.
KW - Contextual processing
KW - Emotion recognition
KW - Empathy
KW - First-degree asymptomatic relatives
KW - Huntington's disease
UR - http://www.scopus.com/inward/record.url?scp=84921307171&partnerID=8YFLogxK
U2 - 10.1016/j.neuropsychologia.2015.01.012
DO - 10.1016/j.neuropsychologia.2015.01.012
M3 - Article
C2 - 25582408
AN - SCOPUS:84921307171
SN - 0028-3932
VL - 68
SP - 158
EP - 167
JO - Neuropsychologia
JF - Neuropsychologia
ER -