@article{6c8f978a5a85488c92839b035efabe7d,
title = "Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes",
abstract = "We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that interindividual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade-albeit in a very limited manner-to behaviors as complex as the choice of one's occupation.",
keywords = "Brain development, Cortical surface area, Cortical thickness, Genome-wide association study, Occupational aptitude",
author = "{the ENIGMA Consortium} and {the neuroCHARGE Working Group} and Jean Shin and Shaojie Ma and Edith Hofer and Yash Patel and Vosberg, {Daniel E.} and Steven Tilley and Roshchupkin, {Gennady V.} and Sousa, {Andr{\'e} M.M.} and Xueqiu Jian and Rebecca Gottesman and Mosley, {Thomas H.} and Myriam Fornage and Yasaman Saba and Lukas Pirpamer and Reinhold Schmidt and Helena Schmidt and Amaia Carrion-Castillo and Fabrice Crivello and Bernard Mazoyer and Bis, {Joshua C.} and Shuo Li and Qiong Yang and Michelle Luciano and Sherif Karama and Lindsay Lewis and Bastin, {Mark E.} and Harris, {Mathew A.} and Wardlaw, {Joanna M.} and Deary, {Ian E.} and Markus Scholz and Markus Loeffler and Witte, {A. Veronica} and Frauke Beyer and Arno Villringer and Armstrong, {Nicola J.} and Mather, {Karen A.} and David Ames and Jiyang Jiang and Kwok, {John B.} and Schofield, {Peter R.} and Anbupalam Thalamuthu and Trollor, {Julian N.} and Wright, {Margaret J.} and Henry Brodaty and Wei Wen and Sachdev, {Perminder S.} and Natalie Terzikhan and Evans, {Tavia E.} and Adams, {Hieab H.H.H.} and Ikram, {M. Arfan}",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2018.",
year = "2020",
doi = "10.1093/CERCOR/BHAA035",
language = "English",
volume = "30",
pages = "4121--4139",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "7",
}