TY - JOUR
T1 - Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes
AU - the Early Growth Genetics Consortium
AU - Vogelezang, Suzanne
AU - Bradfield, Jonathan P.
AU - Johansson, Stefan
AU - Stergiakouli, Evie
AU - Thiering, Elisabeth
AU - Pennell, Craig E.
AU - Ahluwalia, Tarunveer S.
AU - Karhunen, Ville
AU - Scholz, Markus
AU - Liu, Xueping
AU - Iñiguez, Carmen
AU - Raitakari, Olli T.
AU - Bacelis, Jonas
AU - Schnurr, Theresia M.
AU - Lakka, Timo A.
AU - Ntalla, Ioanna
AU - Lind, Mads V.
AU - Lauritzen, Lotte
AU - Herrala, Sauli
AU - Lin, Frederick T.J.
AU - Frithioff-Bøjsøe, Christine
AU - Beaumont, Robin N.
AU - Zafarmand, Mohammed H.
AU - Rzehak, Peter
AU - Bilbao, Jose R.
AU - Junna, Nella
AU - Vonk, Judith M.
AU - Rifas-Shiman, Sheryl L.
AU - Janjanam, Vimala D.
AU - Knol, Maria J.
AU - Ramdas, Shweta
AU - Beilin, Lawrie
AU - Bønnelykke, Klaus
AU - Casas, Maribel
AU - Eriksson, Johan G.
AU - Escribano, Joaquin
AU - Evans, Tavia E.
AU - Gehring, Ulrike
AU - Geller, Frank
AU - Grote, Veit
AU - Gruszfeld, Darek
AU - Hakonarson, Hakon
AU - Hattersley, Andrew T.
AU - Have, Christian T.
AU - Geoffrey Hayes, M.
AU - Heinrich, Joachim
AU - Helgeland, Øvind
AU - Holloway, Jhon
AU - Joro, Raimo
AU - Adams, Hieab H.H.
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Background: Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
AB - Background: Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
KW - Genetic correlations
KW - Genome-wide association study
KW - Head circumference
KW - Infancy
UR - http://www.scopus.com/inward/record.url?scp=85137679586&partnerID=8YFLogxK
U2 - 10.1186/s12920-022-01281-1
DO - 10.1186/s12920-022-01281-1
M3 - Article
C2 - 35659227
AN - SCOPUS:85137679586
SN - 1755-8794
VL - 15
JO - BMC Medical Genomics
JF - BMC Medical Genomics
IS - 1
M1 - 124
ER -