TY - CHAP
T1 - Disruptions of frontostriatal language functions in Parkinson’s disease
AU - García, Adolfo M.
AU - Bocanegra, Yamile
AU - Birba, Agustina
AU - Orozco-Arroyave, Juan Rafael
AU - Sedeño, Lucas
AU - Ibáñez, Agustín
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Atrophy of frontostriatal pathways in Parkinson’s disease compromises diverse linguistic functions. To establish which of these disorders constitute candidate cognitive biomarkers of the disease, we review studies assessing phonetic/phonological, morphological, lexicosemantic, syntactic, and discourse-level dimensions in early stage patients. While morphological difficulties are inconsistent and discourse-level alterations seem nosologically unspecific, systematic disturbances emerge in particular phonetic (plosive articulation), lexicosemantic (action-verb processing), and syntactic (complex-sentence parsing) functions. Some such deficits are selective (not generalized across their overarching domain), partially specific (absent in nonmotor disorders), primary (not secondary to overall cognitive dysfunction), associated with critical neurobiological abnormalities, and traceable in prodromal stages. Notably, new approaches for analyzing those dimensions allow identifying individual patients with over 90% accuracy. Although several challenges remain unaddressed and more programmatic research is needed, the incorporation of these tools in clinical settings could enhance screening protocols, differential diagnosis, disease-progression monitoring, and discrimination of patient profiles within the parkinsonian population.
AB - Atrophy of frontostriatal pathways in Parkinson’s disease compromises diverse linguistic functions. To establish which of these disorders constitute candidate cognitive biomarkers of the disease, we review studies assessing phonetic/phonological, morphological, lexicosemantic, syntactic, and discourse-level dimensions in early stage patients. While morphological difficulties are inconsistent and discourse-level alterations seem nosologically unspecific, systematic disturbances emerge in particular phonetic (plosive articulation), lexicosemantic (action-verb processing), and syntactic (complex-sentence parsing) functions. Some such deficits are selective (not generalized across their overarching domain), partially specific (absent in nonmotor disorders), primary (not secondary to overall cognitive dysfunction), associated with critical neurobiological abnormalities, and traceable in prodromal stages. Notably, new approaches for analyzing those dimensions allow identifying individual patients with over 90% accuracy. Although several challenges remain unaddressed and more programmatic research is needed, the incorporation of these tools in clinical settings could enhance screening protocols, differential diagnosis, disease-progression monitoring, and discrimination of patient profiles within the parkinsonian population.
KW - Cognitive biomarkers
KW - Discourse-level processing
KW - Frontostriatal pathways
KW - Lexicosemantics
KW - Morphology
KW - Neurolinguistics
KW - Parkinson’s disease
KW - Phonetics/phonology
KW - Syntax
UR - http://www.scopus.com/inward/record.url?scp=85091559360&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-815950-7.00026-6
DO - 10.1016/B978-0-12-815950-7.00026-6
M3 - Chapter
AN - SCOPUS:85091559360
SP - 413
EP - 430
BT - Genetics, Neurology, Behavior, and Diet in Parkinson’s Disease
PB - Elsevier
ER -