Deconstruction and Dynamical Robustness of Regulatory Networks: Application to the Yeast Cell Cycle Networks

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

26 Citas (Scopus)

Resumen

Analyzing all the deterministic dynamics of a Boolean regulatory network is a difficult problem since it grows exponentially with the number of nodes. In this paper, we present mathematical and computational tools for analyzing the complete deterministic dynamics of Boolean regulatory networks. For this, the notion of alliance is introduced, which is a subconfiguration of states that remains fixed regardless of the values of the other nodes. Also, equivalent classes are considered, which are sets of updating schedules which have the same dynamics. Using these techniques, we analyze two yeast cell cycle models. Results show the effectiveness of the proposed tools for analyzing update robustness as well as the discovery of new information related to the attractors of the yeast cell cycle models considering all the possible deterministic dynamics, which previously have only been studied considering the parallel updating scheme.

Idioma originalInglés
Páginas (desde-hasta)939-966
Número de páginas28
PublicaciónBulletin of Mathematical Biology
Volumen75
N.º6
DOI
EstadoPublicada - jun. 2013

Huella

Profundice en los temas de investigación de 'Deconstruction and Dynamical Robustness of Regulatory Networks: Application to the Yeast Cell Cycle Networks'. En conjunto forman una huella única.

Citar esto