Convergence of interoception, emotion, and social cognition: A twofold fMRI meta-analysis and lesion approach

Federico Adolfi, Blas Couto, Fabian Richter, Jean Decety, Jessica Lopez, Mariano Sigman, Facundo Manes, Agustín Ibáñez

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

171 Citas (Scopus)

Resumen

Guided by indirect evidence, recent approaches propose a tripartite crosstalk among interoceptive signaling, emotional regulation, and low-level social cognition. Here we examined the neurocognitive convergence of such domains. First, we performed three meta-analyses of functional magnetic resonance imaging studies to identify which areas are consistently coactivated by these three systems. Multi-level Kernel Density Analysis (MKDA) revealed major overlaps in the right anterior insular and frontotemporal regions (viz., the orbitofrontal and inferior frontal gyri, the amygdala, and mid temporal lobe/subcortical structures). Second, we explored such domains in patients with fronto-insulo-temporal damage. Relative to controls, the patients showed behavioral impairments of interoception, emotional processing, and social cognition, with preservation of other cognitive functions. Convergent results from both studies offer direct support for a model of insular-frontotemporal regions integrating interoception, emotion, and social cognition.

Idioma originalInglés
Páginas (desde-hasta)124-142
Número de páginas19
PublicaciónCortex
Volumen88
DOI
EstadoPublicada - 1 mar. 2017
Publicado de forma externa

Huella

Profundice en los temas de investigación de 'Convergence of interoception, emotion, and social cognition: A twofold fMRI meta-analysis and lesion approach'. En conjunto forman una huella única.

Citar esto