Computational and experimental investigation of molecular imprinted polymers for selective extraction of dimethoate and its metabolite omethoate from olive oil

Idriss Bakas, Najwa Ben Oujji, Ewa Moczko, Georges Istamboulie, Sergey Piletsky, Elena Piletska, Elhabib Ait-Addi, Ihya Ait-Ichou, Thierry Noguer, Régis Rouillon

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

55 Citas (Scopus)

Resumen

This work presents the development of molecularly imprinted polymers (MIPs) for the selective extraction of dimethoate from olive oil. Computational simulations allowed selecting itaconic acid as the monomer showing the highest affinity towards dimethoate. Experimental validation confirmed modelling predictions and showed that the polymer based on IA as functional monomer and omethoate as template molecule displays the highest selectivity for the structurally similar pesticides dimethoate, omethoate and monocrotophos. Molecularly imprinted solid phase extraction (MISPE) method was developed and applied to the clean-up of olive oil extracts. It was found that the most suitable solvents for loading, washing and elution step were respectively hexane, hexane-dichloromethane (85:15%) and methanol. The developed MIPSE was successfully applied to extraction of dimethoate from olive oil, with recovery rates up to 94%. The limits of detection and quantification of the described method were respectively 0.012 and 0.05μgg-1.

Idioma originalInglés
Páginas (desde-hasta)13-18
Número de páginas6
PublicaciónJournal of Chromatography A
Volumen1274
DOI
EstadoPublicada - 25 ene. 2013
Publicado de forma externa

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