In Chile, office buildings are typically reinforced concrete (RC) structures whose lateral load-resisting system comprises core structural walls and perimeter moment frames (i.e., dual wall-frame system). In the last 20 years, nearly 800 new dual wall-frame buildings have been built in the country and roughly 70% of them have less than ten stories. Although the seismic performance of these structures was deemed satisfactory in previous earthquakes, their actual collapse potential is indeed unknown. In this study, the collapse performance of Chilean code-conforming mid-rise RC buildings is assessed considering different hazard levels (i.e., high and moderate seismic activity) and different soil types (i.e., stiff and moderately stiff). Following the FEMA P-58 methodology, 3D nonlinear models of four representative structural archetypes were subjected to sets of Chilean subduction ground motions. Incremental dynamic analysis was used to develop collapse fragilities. The results indicate that the archetypes comply with the ‘life safety’ risk level defined in ASCE 7, which is consistent with the observed seismic behavior in recent mega-earthquakes in Chile. However, the collapse risk is not uniform. Differences in collapse probabilities are significant, which might indicate that revisions to the current Chilean seismic design code might be necessary.