TY - JOUR
T1 - Brain resting state is disrupted in chronic back pain patients
AU - Tagliazucchi, Enzo
AU - Balenzuela, Pablo
AU - Fraiman, Daniel
AU - Chialvo, Dante R.
N1 - Funding Information:
Work supported by NIH of USA , grant NS58661 and by CONICET . E.T. was supported by an Estimulo Fellowship from the University of Buenos Aires . Data collection was funded by grant NS35115 (awarded to A.V. Apkarian) by NIH . We thank P. Montoya, O. Scremin, M. Zirovich, T. Victor and P. Bharath for comments.
PY - 2010/11
Y1 - 2010/11
N2 - Recent brain functional magnetic resonance imaging (fMRI) studies have shown that chronic back pain (CBP) alters brain dynamics beyond the feeling of pain. In particular, the response of the brain default mode network (DMN) during an attention task was found abnormal. In the present work similar alterations are demonstrated for spontaneous resting patterns of fMRI brain activity over a population of CBP patients (n= 12, 29-67 years old, mean = 51.2). Results show abnormal correlations of three out of four highly connected sites of the DMN with bilateral insular cortex and regions in the middle frontal gyrus (p< 0.05), in comparison with a control group of healthy subjects (n= 20, 21-60 years old, mean = 38.4). The alterations were confirmed by the calculation of triggered averages, which demonstrated increased coactivation of the DMN and the former regions. These findings demonstrate that CBP disrupts normal activity in the DMN even during the brain resting state, highlighting the impact of enduring pain over brain structure and function.
AB - Recent brain functional magnetic resonance imaging (fMRI) studies have shown that chronic back pain (CBP) alters brain dynamics beyond the feeling of pain. In particular, the response of the brain default mode network (DMN) during an attention task was found abnormal. In the present work similar alterations are demonstrated for spontaneous resting patterns of fMRI brain activity over a population of CBP patients (n= 12, 29-67 years old, mean = 51.2). Results show abnormal correlations of three out of four highly connected sites of the DMN with bilateral insular cortex and regions in the middle frontal gyrus (p< 0.05), in comparison with a control group of healthy subjects (n= 20, 21-60 years old, mean = 38.4). The alterations were confirmed by the calculation of triggered averages, which demonstrated increased coactivation of the DMN and the former regions. These findings demonstrate that CBP disrupts normal activity in the DMN even during the brain resting state, highlighting the impact of enduring pain over brain structure and function.
KW - Brain
KW - Chronic pain
KW - Default mode network
KW - FMRI
KW - Functional connectivity
KW - Resting state networks
UR - https://www.scopus.com/pages/publications/77957238500
U2 - 10.1016/j.neulet.2010.08.053
DO - 10.1016/j.neulet.2010.08.053
M3 - Article
C2 - 20800649
AN - SCOPUS:77957238500
SN - 0304-3940
VL - 485
SP - 26
EP - 31
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -