TY - JOUR
T1 - Balancing equity and efficiency in kidney allocation
T2 - An online adaptive stochastic bi-objective approach
AU - Cantarino, Daniela
AU - Acuna, Jorge A.
AU - Stevens, Monica
AU - Heide, Mckenzi
AU - Zayas-Castro, José L.
N1 - Publisher Copyright:
© 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
PY - 2026/5/1
Y1 - 2026/5/1
N2 - Kidney allocation presents a persistent trade-off between medical urgency (equity) and post-transplant survival (efficiency). This paper introduces an intelligent decision-support system that integrates stochastic optimization and game-theoretic reasoning to balance these competing objectives under uncertainty. We formulate a bi-objective stochastic model that compares pre-transplant mortality risk and expected post-transplant survival while enforcing regional chance constraints to limit graft-failure rates. To identify a fair and actionable policy, the framework applies the Nash Bargaining Solution to select a balanced compromise on the Pareto frontier. The resulting weights are then incorporated into an online adaptive two-stage stochastic program, enabling real-time allocation of newly available kidneys based on historical performance and predicted future capacity. Using national US waiting list data, the proposed system increases monthly deceased-donor transplants by 4.5%, reduces graft-failure probability by 6.22%, and raises average expected survival by 22.95%, while improving access for high-urgency candidates by 15%. These results demonstrate how combining optimization and adaptive learning principles can yield an intelligent, equitable, and efficient decision-support system for organ transplantation.
AB - Kidney allocation presents a persistent trade-off between medical urgency (equity) and post-transplant survival (efficiency). This paper introduces an intelligent decision-support system that integrates stochastic optimization and game-theoretic reasoning to balance these competing objectives under uncertainty. We formulate a bi-objective stochastic model that compares pre-transplant mortality risk and expected post-transplant survival while enforcing regional chance constraints to limit graft-failure rates. To identify a fair and actionable policy, the framework applies the Nash Bargaining Solution to select a balanced compromise on the Pareto frontier. The resulting weights are then incorporated into an online adaptive two-stage stochastic program, enabling real-time allocation of newly available kidneys based on historical performance and predicted future capacity. Using national US waiting list data, the proposed system increases monthly deceased-donor transplants by 4.5%, reduces graft-failure probability by 6.22%, and raises average expected survival by 22.95%, while improving access for high-urgency candidates by 15%. These results demonstrate how combining optimization and adaptive learning principles can yield an intelligent, equitable, and efficient decision-support system for organ transplantation.
KW - Healthcare decision analytics
KW - Healthcare management
KW - Kidney transplantation
KW - Multi-objective optimization
KW - Organ allocation
KW - Stochastic programming
UR - https://www.scopus.com/pages/publications/105029592335
U2 - 10.1016/j.eswa.2026.131148
DO - 10.1016/j.eswa.2026.131148
M3 - Article
AN - SCOPUS:105029592335
SN - 0957-4174
VL - 308
JO - Expert Systems with Applications
JF - Expert Systems with Applications
M1 - 131148
ER -