TY - JOUR
T1 - Amyloid aggregates
T2 - Role in protein misfolding disorders
AU - Duran-Aniotz, Claudia
AU - Moreno-Gonzalez, Inés
AU - Morales, Rodrigo
PY - 2013/4
Y1 - 2013/4
N2 - Misfolding and aggregation of proteins are the main features of a group of diseases termed Protein Misfolding Disorders (PMDs). PMDs include Alzheimer's disease and Transmissible Spongiform Encephalopathies, among many others. The deposition of protein aggregates is the main responsible for tissue damage and the consequent clinical signs generated in such disorders. In this review, we will focus in the role of protein aggregates in these diseases and in the putative mechanisms by which they exert their toxicity.
AB - Misfolding and aggregation of proteins are the main features of a group of diseases termed Protein Misfolding Disorders (PMDs). PMDs include Alzheimer's disease and Transmissible Spongiform Encephalopathies, among many others. The deposition of protein aggregates is the main responsible for tissue damage and the consequent clinical signs generated in such disorders. In this review, we will focus in the role of protein aggregates in these diseases and in the putative mechanisms by which they exert their toxicity.
KW - Alzheimers disease
KW - Amyloid
KW - Prion diseases
KW - Protein misfolding
KW - Protestasis deficiencies
UR - http://www.scopus.com/inward/record.url?scp=84880840072&partnerID=8YFLogxK
U2 - 10.4067/S0034-98872013000400011
DO - 10.4067/S0034-98872013000400011
M3 - Article
C2 - 23900371
AN - SCOPUS:84880840072
SN - 0034-9887
VL - 141
SP - 495
EP - 505
JO - Revista Medica de Chile
JF - Revista Medica de Chile
IS - 4
ER -