Whole-brain models to explore altered states of consciousness from the bottom up

Rodrigo Cofré, Rubén Herzog, Pedro A.M. Mediano, Juan Piccinini, Fernando E. Rosas, Yonatan Sanz Perl, Enzo Tagliazucchi

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


The scope of human consciousness includes states departing from what most of us experience as ordinary wakefulness. These altered states of consciousness constitute a prime opportunity to study how global changes in brain activity relate to different varieties of subjective experience. We consider the problem of explaining how global signatures of altered consciousness arise from the interplay between large-scale connectivity and local dynamical rules that can be traced to known properties of neural tissue. For this purpose, we advocate a research program aimed at bridging the gap between bottom-up generative models of whole-brain activity and the top-down signatures proposed by theories of consciousness. Throughout this paper, we define altered states of consciousness, discuss relevant signatures of consciousness observed in brain activity, and introduce whole-brain models to explore the biophysics of altered consciousness from the bottom-up. We discuss the potential of our proposal in view of the current state of the art, give specific examples of how this research agenda might play out, and emphasize how a systematic investigation of altered states of consciousness via bottom-up modeling may help us better understand the biophysical, informational, and dynamical underpinnings of consciousness.

Original languageEnglish
Article number626
Pages (from-to)1-29
Number of pages29
JournalBrain Sciences
Issue number9
StatePublished - Sep 2020
Externally publishedYes


  • Altered states of consciousness
  • Integrated information theory
  • Psychedelics
  • Signatures of consciousness
  • Whole-brain models


Dive into the research topics of 'Whole-brain models to explore altered states of consciousness from the bottom up'. Together they form a unique fingerprint.

Cite this