Unspeakable motion: Selective action-verb impairments in Parkinson's disease patients without mild cognitive impairment

Yamile Bocanegra, Adolfo M. García, Francisco Lopera, David Pineda, Ana Baena, Paula Ospina, Diana Alzate, Omar Buriticá, Leonardo Moreno, Agustín Ibáñez, Fernando Cuetos

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Parkinson's disease (PD) patients show marked impairments in processing action verbs, and to a lesser extent, concrete (specially, manipulable) nouns. However, it is still unclear to what extent deficits in each of these categories are influenced by more general cognitive dysfunctions, and whether they are modulated by the words’ implied motility. To examine these issues, we evaluated 49 non-demented PD patients and 49 healthy volunteers in an oral production task. The patients were divided into two groups depending on the presence or absence of mild cognitive impairment (PD-MCI and PD-nMCI, respectively). Participants named pictures of actions varying in motion content (low and high) and of objects varying in manipulability (low and high). The PD-MCI group showed deficits across all four categories. However, PD-nMCI patients exhibited a selective difficulty for high-motion action verbs. This finding corroborates and refines previous results suggesting that disturbances of action-related lexico-semantic information in PD constitute a sui generis alteration manifested early in the course of the disease's physiopathology. Moreover, it suggests that the grounding of action verbs on motor circuits could depend on fine-grained intracategorical semantic distinctions.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalBrain and Language
Volume168
DOIs
StatePublished - 1 May 2017

Keywords

  • Action verbs
  • Manipulable nouns
  • Mild cognitive impairment
  • Motor semantics
  • Parkinson's disease
  • Picture naming

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