Transforming growth factor-beta superfamily regulates mesenchymal stem cell osteogenic differentiation: A microRNA linking

Juan F. Santibanez; Cesar Echeverria; Carola Millan; Felipe Simon

doi:10.1016/j.acthis.2023.152096

Transforming growth factor-beta superfamily regulates mesenchymal stem cell osteogenic differentiation: A microRNA linking

Juan F. Santibanez, Cesar Echeverria, Carola Millan, Felipe Simon

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

The ability to differentiate into cells of different lineages, such as bone cells, is the principal value of adult mesenchymal stem cells (MSCs), which can be used with the final aim of regenerating damaged tissue. Due to its potential use and importance in regenerative medicine and tissue engineering, several questions have been raised regarding the molecular mechanisms of MSC differentiation. As one of the crucial mediators in organism development, the transforming growth factor-beta (TGF-β) superfamily directs MSCs’ commitment to selecting differentiation pathways. This review aims to give an overview of the current knowledge on the mechanisms of the TGF-β superfamily in MSCs bone differentiation, with additional insight into the mutual regulation of microRNAs and TGF-β in osteogenesis.

Original language	English
Article number	152096
Journal	Acta Histochemica
Volume	125
Issue number	8
DOIs	https://doi.org/10.1016/j.acthis.2023.152096
State	Published - Dec 2023
Externally published	Yes

Keywords

Bone Morphogenetic Proteins
Differentiation
Mesenchymal Stem Cells
MicroRNA
Osteogenic
Transforming Growth Factor-β

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10.1016/j.acthis.2023.152096

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title = "Transforming growth factor-beta superfamily regulates mesenchymal stem cell osteogenic differentiation: A microRNA linking",

abstract = "The ability to differentiate into cells of different lineages, such as bone cells, is the principal value of adult mesenchymal stem cells (MSCs), which can be used with the final aim of regenerating damaged tissue. Due to its potential use and importance in regenerative medicine and tissue engineering, several questions have been raised regarding the molecular mechanisms of MSC differentiation. As one of the crucial mediators in organism development, the transforming growth factor-beta (TGF-β) superfamily directs MSCs{\textquoteright} commitment to selecting differentiation pathways. This review aims to give an overview of the current knowledge on the mechanisms of the TGF-β superfamily in MSCs bone differentiation, with additional insight into the mutual regulation of microRNAs and TGF-β in osteogenesis.",

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T2 - A microRNA linking

AU - Santibanez, Juan F.

AU - Echeverria, Cesar

AU - Millan, Carola

AU - Simon, Felipe

PY - 2023/12

Y1 - 2023/12

N2 - The ability to differentiate into cells of different lineages, such as bone cells, is the principal value of adult mesenchymal stem cells (MSCs), which can be used with the final aim of regenerating damaged tissue. Due to its potential use and importance in regenerative medicine and tissue engineering, several questions have been raised regarding the molecular mechanisms of MSC differentiation. As one of the crucial mediators in organism development, the transforming growth factor-beta (TGF-β) superfamily directs MSCs’ commitment to selecting differentiation pathways. This review aims to give an overview of the current knowledge on the mechanisms of the TGF-β superfamily in MSCs bone differentiation, with additional insight into the mutual regulation of microRNAs and TGF-β in osteogenesis.

AB - The ability to differentiate into cells of different lineages, such as bone cells, is the principal value of adult mesenchymal stem cells (MSCs), which can be used with the final aim of regenerating damaged tissue. Due to its potential use and importance in regenerative medicine and tissue engineering, several questions have been raised regarding the molecular mechanisms of MSC differentiation. As one of the crucial mediators in organism development, the transforming growth factor-beta (TGF-β) superfamily directs MSCs’ commitment to selecting differentiation pathways. This review aims to give an overview of the current knowledge on the mechanisms of the TGF-β superfamily in MSCs bone differentiation, with additional insight into the mutual regulation of microRNAs and TGF-β in osteogenesis.

KW - Bone Morphogenetic Proteins

KW - Differentiation

KW - Mesenchymal Stem Cells

KW - MicroRNA

KW - Osteogenic

KW - Transforming Growth Factor-β

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DO - 10.1016/j.acthis.2023.152096

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Transforming growth factor-beta superfamily regulates mesenchymal stem cell osteogenic differentiation: A microRNA linking

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Keywords

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