Transforming growth factor-beta superfamily regulates mesenchymal stem cell osteogenic differentiation: A microRNA linking

Juan F. Santibanez, Cesar Echeverria, Carola Millan, Felipe Simon

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The ability to differentiate into cells of different lineages, such as bone cells, is the principal value of adult mesenchymal stem cells (MSCs), which can be used with the final aim of regenerating damaged tissue. Due to its potential use and importance in regenerative medicine and tissue engineering, several questions have been raised regarding the molecular mechanisms of MSC differentiation. As one of the crucial mediators in organism development, the transforming growth factor-beta (TGF-β) superfamily directs MSCs’ commitment to selecting differentiation pathways. This review aims to give an overview of the current knowledge on the mechanisms of the TGF-β superfamily in MSCs bone differentiation, with additional insight into the mutual regulation of microRNAs and TGF-β in osteogenesis.

Original languageEnglish
Article number152096
JournalActa Histochemica
Volume125
Issue number8
DOIs
StatePublished - Dec 2023
Externally publishedYes

Keywords

  • Bone Morphogenetic Proteins
  • Differentiation
  • Mesenchymal Stem Cells
  • MicroRNA
  • Osteogenic
  • Transforming Growth Factor-β

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