TY - JOUR
T1 - The impact of loneliness and social adaptation on depressive symptoms
T2 - Behavioral and brain measures evidence from a brain health perspective
AU - Franco-O´Byrne, Daniel
AU - Gonzalez-Gomez, Raul
AU - Morales Sepúlveda, Juan Pablo
AU - Vergara, Mayte
AU - Ibañez, Agustin
AU - Huepe, David
N1 - Publisher Copyright:
Copyright © 2023 Franco-O´Byrne, Gonzalez-Gomez, Morales Sepúlveda, Vergara, Ibañez and Huepe.
PY - 2023
Y1 - 2023
N2 - Introduction: Early detection of depression is a cost-effective way to prevent adverse outcomes on brain physiology, cognition, and health. Here we propose that loneliness and social adaptation are key factors that can anticipate depressive symptoms. Methods: We analyzed data from two separate samples to evaluate the associations between loneliness, social adaptation, depressive symptoms, and their neural correlates. Results: For both samples, hierarchical regression models on self-reported data showed that loneliness and social adaptation have negative and positive effects on depressive symptoms. Moreover, social adaptation reduces the impact of loneliness on depressive symptoms. Structural connectivity analysis showed that depressive symptoms, loneliness, and social adaptation share a common neural substrate. Furthermore, functional connectivity analysis demonstrated that only social adaptation was associated with connectivity in parietal areas. Discussion: Altogether, our results suggest that loneliness is a strong risk factor for depressive symptoms while social adaptation acts as a buffer against the ill effects of loneliness. At the neuroanatomical level, loneliness and depression may affect the integrity of white matter structures known to be associated to emotion dysregulation and cognitive impairment. On the other hand, socio-adaptive processes may protect against the harmful effects of loneliness and depression. Structural and functional correlates of social adaptation could indicate a protective role through long and short-term effects, respectively. These findings may aid approaches to preserve brain health via social participation and adaptive social behavior.
AB - Introduction: Early detection of depression is a cost-effective way to prevent adverse outcomes on brain physiology, cognition, and health. Here we propose that loneliness and social adaptation are key factors that can anticipate depressive symptoms. Methods: We analyzed data from two separate samples to evaluate the associations between loneliness, social adaptation, depressive symptoms, and their neural correlates. Results: For both samples, hierarchical regression models on self-reported data showed that loneliness and social adaptation have negative and positive effects on depressive symptoms. Moreover, social adaptation reduces the impact of loneliness on depressive symptoms. Structural connectivity analysis showed that depressive symptoms, loneliness, and social adaptation share a common neural substrate. Furthermore, functional connectivity analysis demonstrated that only social adaptation was associated with connectivity in parietal areas. Discussion: Altogether, our results suggest that loneliness is a strong risk factor for depressive symptoms while social adaptation acts as a buffer against the ill effects of loneliness. At the neuroanatomical level, loneliness and depression may affect the integrity of white matter structures known to be associated to emotion dysregulation and cognitive impairment. On the other hand, socio-adaptive processes may protect against the harmful effects of loneliness and depression. Structural and functional correlates of social adaptation could indicate a protective role through long and short-term effects, respectively. These findings may aid approaches to preserve brain health via social participation and adaptive social behavior.
KW - brain health
KW - depressive symptoms
KW - loneliness
KW - neural correlates
KW - social adaptation
UR - http://www.scopus.com/inward/record.url?scp=85151442335&partnerID=8YFLogxK
U2 - 10.3389/fpsyg.2023.1096178
DO - 10.3389/fpsyg.2023.1096178
M3 - Article
AN - SCOPUS:85151442335
SN - 1664-1078
VL - 14
JO - Frontiers in Psychology
JF - Frontiers in Psychology
M1 - 1096178
ER -