TY - JOUR
T1 - Synergistic impact of nanoarchitectured GQDs-AgNCs(APTS) modified glassy carbon electrode in the electrochemical detection of guanine and adenine
AU - Vinoth, Victor
AU - Kaimal, Reshma
AU - Selvamani, Muthamizh
AU - Michael, Rubina
AU - Pugazhenthiran, Nalandhiran
AU - Mangalaraja, Ramalinga Viswanathan
AU - Valdés, Héctor
AU - Anandan, Sambandam
N1 - Funding Information:
The authors V. Vinoth and H. Valdés gratefully acknowledge the ANID/FONDECYT Post-doctoral Project No. 3190256, Government of Chile, Santiago, for the financial assistance. The author S. Anandan wants to thank SPARC funding agency (SPARC/2018-2019/P236/SL). Ms. Reshma expresses gratitude to the MHRD for funding her Ph. D. fellowship.
Funding Information:
Pugazhenthiran Nalandhiran currently working as an assistant professor of chemistry at the Universidad Tecnica Federico Santa Maria, Valparaiso. Dr. N. Pugazhenthiran obtained his doctoral degree (Ph. D., in Chemistry) at the School of Chemistry, Madurai Kamaraj University, Madurai, India. He got four research grants from ANID-FONDECYT and ANID-FONDEF, the Government of Chile from the period of November 2015 to March 2023. Moreover, he has published 32 scientific articles in WoS-indexed Journals. Additionally, he has published four book chapters and granted two patents in his credit. His research focuses on the development of nanostructured materials for energy and environmental applications.
Funding Information:
Muthamizh Selvamani working as an Assistant Professor-Research in the Department of Physiology at Saveetha Dental College and Hospital. She pursued her Doctor of Philosophy (2013-2018) in Inorganic Chemistry at the University of Madras, Chennai, India. During her Ph.D., She was worked as Junior Research Fellow in UGC-UPE Phase-II Project and received a NAMASTE INDO-EUROPE Visiting Fellowship to work at the Department of Chemistry, Universitat Politècnica de València, Spain. The NAMASTE INDO-EUROPE Fellowship was hosted by Prof. Ramon Martinez-Manez. After the successful completion of the Doctoral thesis, Dr. Muthamizh received India’s Prestigious Fellowship called National Post-Doctoral Fellowship (NPDF) awarded (2017-2019) by the Department of Science and Technology (SERB), India. This fellowship was hosted by Prof. R. Jayavel at Crystal Growth Center, Anna University, Chennai. After the completion of NPDF, Dr. Muthamizh worked as a FONDEYT Postdoctoral Fellowship (2019-2022) in Chile, Lattin America. This fellowship was carried out at the University of Concepcion, Chile under the Guidance of Prof. David Contreras. Dr. Muthamizh’s research interest includes the Synthesis of Nanomaterials and Polymer Nanocomposites, Electro-chemical Biosensors, photocatalysts, Super-capacitor, and Hydrogen Evolution reactions. From her research outcomes, she published more than 37 papers and articles in both national and international journals with a Scopus H index of 16 and a total citation of 752.
Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/4/1
Y1 - 2023/4/1
N2 - In this work, a facile green approach for the synthesis of graphene quantum dots (GQDs) embedded on silicate network silver nanocrystals (GQDs-AgNCs(APTS)) is reported. Moreover, glassy carbon-GC electrodes were modified with the prepared nanocomposite containing graphene quantum dots supported on silver nanocrystals (GQDs-AgNCs(APTS)) and applied for simultaneous detection of guanine (GA) and adenine (AD). The chemically modified electrode was assessed during the determination of purine bases by cyclic voltammetry-CV and differential pulse voltammetry-DPV. The incorporation of GQDs-AgNCs(APTS) nanocomposites over the surface of the GC electrode considerably enhances the anodic peak currents and decreases the adenine and guanine peak potentials. Compared to other electrodes, GQDs-AgNCs(APTS)/GC improved the electrochemical behavior towards the detection of adenine and guanine. At optimal conditions, calibration curves were obtained by DPV being linear in the range of 0.1–6.0 μM and 0.1–5.0 μM for guanine and adenine, respectively. The detection limits of both guanine and adenine were estimated as 0.1 μM. Additionally, interferences analyses were performed on the existence of other interferent compounds. Furthermore, the method developed for the identification of GA and AD was proved using fish sperm DNA samples.
AB - In this work, a facile green approach for the synthesis of graphene quantum dots (GQDs) embedded on silicate network silver nanocrystals (GQDs-AgNCs(APTS)) is reported. Moreover, glassy carbon-GC electrodes were modified with the prepared nanocomposite containing graphene quantum dots supported on silver nanocrystals (GQDs-AgNCs(APTS)) and applied for simultaneous detection of guanine (GA) and adenine (AD). The chemically modified electrode was assessed during the determination of purine bases by cyclic voltammetry-CV and differential pulse voltammetry-DPV. The incorporation of GQDs-AgNCs(APTS) nanocomposites over the surface of the GC electrode considerably enhances the anodic peak currents and decreases the adenine and guanine peak potentials. Compared to other electrodes, GQDs-AgNCs(APTS)/GC improved the electrochemical behavior towards the detection of adenine and guanine. At optimal conditions, calibration curves were obtained by DPV being linear in the range of 0.1–6.0 μM and 0.1–5.0 μM for guanine and adenine, respectively. The detection limits of both guanine and adenine were estimated as 0.1 μM. Additionally, interferences analyses were performed on the existence of other interferent compounds. Furthermore, the method developed for the identification of GA and AD was proved using fish sperm DNA samples.
KW - Adenine
KW - Electrochemical sensors
KW - Fish sperm
KW - Graphene quantum dots
KW - Guanine
KW - Silver nanocrystals
UR - http://www.scopus.com/inward/record.url?scp=85149676771&partnerID=8YFLogxK
U2 - 10.1016/j.jelechem.2023.117302
DO - 10.1016/j.jelechem.2023.117302
M3 - Article
AN - SCOPUS:85149676771
SN - 1572-6657
VL - 934
JO - Journal of Electroanalytical Chemistry
JF - Journal of Electroanalytical Chemistry
M1 - 117302
ER -