Surface-modified multifunctional MIP nanoparticles

Ewa Moczko, Alessandro Poma, Antonio Guerreiro, Isabel Perez De Vargas Sansalvador, Sarah Caygill, Francesco Canfarotta, Michael J. Whitcombe, Sergey Piletsky

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


The synthesis of core-shell molecularly imprinted polymer nanoparticles (MIP NPs) has been performed using a novel solid-phase approach on immobilised templates. The same solid phase also acts as a protective functionality for high affinity binding sites during subsequent derivatisation/shell formation. This procedure allows for the rapid synthesis, controlled separation and purification of high-affinity materials, with each production cycle taking just 2 hours. The aim of this approach is to synthesise uniformly sized imprinted materials at the nanoscale which can be readily grafted with various polymers without affecting their affinity and specificity. For demonstration purposes we grafted anti-melamine MIP NPs with coatings which introduce the following surface characteristics: high polarity (PEG methacrylate); electro-activity (vinylferrocene); fluorescence (eosin acrylate); thiol groups (pentaerythritol tetrakis(3-mercaptopropionate)). The method has broad applicability and can be used to produce multifunctional imprinted nanoparticles with potential for further application in the biosensors, diagnostics and biomedical fields and as an alternative to natural receptors.

Original languageEnglish
Pages (from-to)3733-3741
Number of pages9
Issue number9
StatePublished - 7 May 2013
Externally publishedYes


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