TY - JOUR
T1 - Subcortical brain structures and the risk of dementia in the Rotterdam Study
AU - van der Velpen, Isabelle F.
AU - Vlasov, Vanja
AU - Evans, Tavia E.
AU - Ikram, Mohammad Kamran
AU - Gutman, Boris A.
AU - Roshchupkin, Gennady V.
AU - Adams, Hieab H.
AU - Vernooij, Meike W.
AU - Ikram, Mohammad Arfan
N1 - Publisher Copyright:
© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2023/2
Y1 - 2023/2
N2 - Introduction: Volumetric and morphological changes in subcortical brain structures are present in persons with dementia, but it is unknown if these changes occur prior to diagnosis. Methods: Between 2005 and 2016, 5522 Rotterdam Study participants (mean age: 64.4) underwent cerebral magnetic resonance imaging (MRI) and were followed for development of dementia until 2018. Volume and shape measures were obtained for seven subcortical structures. Results: During 12 years of follow-up, 272 dementia cases occurred. Mean volumes of thalamus (hazard ratio [HR] per standard deviation [SD] decrease 1.94, 95% confidence interval [CI]: 1.55–2.43), amygdala (HR 1.66, 95% CI: 1.44–1.92), and hippocampus (HR 1.64, 95% CI: 1.43–1.88) were strongly associated with dementia risk. Associations for accumbens, pallidum, and caudate volumes were less pronounced. Shape analyses identified regional surface changes in the amygdala, limbic thalamus, and caudate. Discussion: Structure of the amygdala, thalamus, hippocampus, and caudate is associated with risk of dementia in a large population-based cohort of older adults.
AB - Introduction: Volumetric and morphological changes in subcortical brain structures are present in persons with dementia, but it is unknown if these changes occur prior to diagnosis. Methods: Between 2005 and 2016, 5522 Rotterdam Study participants (mean age: 64.4) underwent cerebral magnetic resonance imaging (MRI) and were followed for development of dementia until 2018. Volume and shape measures were obtained for seven subcortical structures. Results: During 12 years of follow-up, 272 dementia cases occurred. Mean volumes of thalamus (hazard ratio [HR] per standard deviation [SD] decrease 1.94, 95% confidence interval [CI]: 1.55–2.43), amygdala (HR 1.66, 95% CI: 1.44–1.92), and hippocampus (HR 1.64, 95% CI: 1.43–1.88) were strongly associated with dementia risk. Associations for accumbens, pallidum, and caudate volumes were less pronounced. Shape analyses identified regional surface changes in the amygdala, limbic thalamus, and caudate. Discussion: Structure of the amygdala, thalamus, hippocampus, and caudate is associated with risk of dementia in a large population-based cohort of older adults.
KW - brain
KW - dementia
KW - epidemiology
KW - magnetic resonance imaging
KW - morphology
KW - subcortical
UR - http://www.scopus.com/inward/record.url?scp=85130722363&partnerID=8YFLogxK
U2 - 10.1002/alz.12690
DO - 10.1002/alz.12690
M3 - Article
C2 - 35633518
AN - SCOPUS:85130722363
SN - 1552-5260
VL - 19
SP - 646
EP - 657
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 2
ER -
