TY - JOUR
T1 - Subcortical brain structures and the risk of dementia in the Rotterdam Study
AU - van der Velpen, Isabelle F.
AU - Vlasov, Vanja
AU - Evans, Tavia E.
AU - Ikram, Mohammad Kamran
AU - Gutman, Boris A.
AU - Roshchupkin, Gennady V.
AU - Adams, Hieab H.
AU - Vernooij, Meike W.
AU - Ikram, Mohammad Arfan
N1 - Funding Information:
The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw); the Research Institute for Diseases in the Elderly (RIDE); the Ministry of Education, Culture and Science; the Ministry for Health, Welfare and Sports; the European Commission (DG XII); and the Municipality of Rotterdam. M.W. Vernooij is recipient of ABOARD, which is a public–private partnership receiving funding from ZonMW (#73305095007) and Health∼Holland, Topsector Life Sciences & Health (PPP‐allowance; #LSHM20106). This work was partially supported by the JPND project Social Health and Reserve in the Dementia patient journey (SHARED) and financed through projects funded by the Netherlands Organisation for Health Research and Development (grant numbers 733051082 and 733050831). Parts of this work were presented at the 2017 Alzheimer's Association International Conference; no abstract or other information was published previously. The authors are grateful to the study participants, the staff from the Rotterdam Study, and the participating general practitioners and pharmacists.
Publisher Copyright:
© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2023/2
Y1 - 2023/2
N2 - Introduction: Volumetric and morphological changes in subcortical brain structures are present in persons with dementia, but it is unknown if these changes occur prior to diagnosis. Methods: Between 2005 and 2016, 5522 Rotterdam Study participants (mean age: 64.4) underwent cerebral magnetic resonance imaging (MRI) and were followed for development of dementia until 2018. Volume and shape measures were obtained for seven subcortical structures. Results: During 12 years of follow-up, 272 dementia cases occurred. Mean volumes of thalamus (hazard ratio [HR] per standard deviation [SD] decrease 1.94, 95% confidence interval [CI]: 1.55–2.43), amygdala (HR 1.66, 95% CI: 1.44–1.92), and hippocampus (HR 1.64, 95% CI: 1.43–1.88) were strongly associated with dementia risk. Associations for accumbens, pallidum, and caudate volumes were less pronounced. Shape analyses identified regional surface changes in the amygdala, limbic thalamus, and caudate. Discussion: Structure of the amygdala, thalamus, hippocampus, and caudate is associated with risk of dementia in a large population-based cohort of older adults.
AB - Introduction: Volumetric and morphological changes in subcortical brain structures are present in persons with dementia, but it is unknown if these changes occur prior to diagnosis. Methods: Between 2005 and 2016, 5522 Rotterdam Study participants (mean age: 64.4) underwent cerebral magnetic resonance imaging (MRI) and were followed for development of dementia until 2018. Volume and shape measures were obtained for seven subcortical structures. Results: During 12 years of follow-up, 272 dementia cases occurred. Mean volumes of thalamus (hazard ratio [HR] per standard deviation [SD] decrease 1.94, 95% confidence interval [CI]: 1.55–2.43), amygdala (HR 1.66, 95% CI: 1.44–1.92), and hippocampus (HR 1.64, 95% CI: 1.43–1.88) were strongly associated with dementia risk. Associations for accumbens, pallidum, and caudate volumes were less pronounced. Shape analyses identified regional surface changes in the amygdala, limbic thalamus, and caudate. Discussion: Structure of the amygdala, thalamus, hippocampus, and caudate is associated with risk of dementia in a large population-based cohort of older adults.
KW - brain
KW - dementia
KW - epidemiology
KW - magnetic resonance imaging
KW - morphology
KW - subcortical
UR - http://www.scopus.com/inward/record.url?scp=85130722363&partnerID=8YFLogxK
U2 - 10.1002/alz.12690
DO - 10.1002/alz.12690
M3 - Article
C2 - 35633518
AN - SCOPUS:85130722363
SN - 1552-5260
VL - 19
SP - 646
EP - 657
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 2
ER -
