TY - JOUR
T1 - Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014-2024
AU - Ferreccio, Catterina
AU - Roa, Juan Carlos
AU - Bambs, Claudia
AU - Vives, Alejandra
AU - Corvalán, Alejandro H.
AU - Cortés, Sandra
AU - Foerster, Claudia
AU - Acevedo, Johanna
AU - Huidobro, Andrea
AU - Passi, Alvaro
AU - Toro, Pablo
AU - Covacevich, Yerko
AU - De La Cruz, Rolando
AU - Koshiol, Jill
AU - Olivares, Mauricio
AU - Miquel, Juan Francisco
AU - Cruz, Francisco
AU - Silva, Raúl
AU - Quest, Andrew F.
AU - Kogan, Marcelo J.
AU - Castro, Pablo F.
AU - Lavandero, Sergio
N1 - Publisher Copyright:
© 2016 Ferreccio et al.
PY - 2016/2/4
Y1 - 2016/2/4
N2 - Background: Maule Cohort (MAUCO), a Chilean cohort study, seeks to analyze the natural history of chronic diseases in the agricultural county of Molina (40,000 inhabitants) in the Maule Region, Chile. Molinás population is of particular interest because in the last few decades it changed from being undernourished to suffering excess caloric intake, and it currently has the highest national rates of cardiovascular diseases, stomach cancer and gallbladder cancer. Between 2009 and 2011 Molinás poverty rate dropped from 24.1 % to 13.5 % (national average 20.4 %); in this period the county went from insufficient to almost complete basic sanitation. Despite these advances, chemical pollutants in the food and air are increasing. Thus, in Molina risk factors typical of both under-developed and developed countries coexist, generating a unique profile associated with inflammation, oxidative stress and chronic diseases. Methods/Design: MAUCO is the core project of the recently established Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile & Pontificia Universidad Católica de Chile. In this study, we are enrolling and following 10,000 adults aged 38 to 74 years over 10 years. All eligible Molina residents will be enrolled. Participants were identified through a household census. Consenting individuals answer an epidemiological survey exploring risk factors (psycho-social, pesticides, diet, alcohol, and physical activity), medical history and physical and cognitive conditions; provide fasting blood, urine, and saliva samples; receive an electrocardiogram, abdominal ultrasound and bio-impedance test; and take a hand-grip strength test. These subjects will be re-interviewed after 2, 5 and 7 years. Active surveillance of health events is in place throughout the regional healthcare system. The MAUCO Bio-Bank will store 30 to 50 aliquots per subject using an NIH/NCI biorepository system for secure and anonymous linkage of samples with data. Discussion: MAUCÓs results will help design public health interventions tailored to agricultural populations in Latin America.
AB - Background: Maule Cohort (MAUCO), a Chilean cohort study, seeks to analyze the natural history of chronic diseases in the agricultural county of Molina (40,000 inhabitants) in the Maule Region, Chile. Molinás population is of particular interest because in the last few decades it changed from being undernourished to suffering excess caloric intake, and it currently has the highest national rates of cardiovascular diseases, stomach cancer and gallbladder cancer. Between 2009 and 2011 Molinás poverty rate dropped from 24.1 % to 13.5 % (national average 20.4 %); in this period the county went from insufficient to almost complete basic sanitation. Despite these advances, chemical pollutants in the food and air are increasing. Thus, in Molina risk factors typical of both under-developed and developed countries coexist, generating a unique profile associated with inflammation, oxidative stress and chronic diseases. Methods/Design: MAUCO is the core project of the recently established Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile & Pontificia Universidad Católica de Chile. In this study, we are enrolling and following 10,000 adults aged 38 to 74 years over 10 years. All eligible Molina residents will be enrolled. Participants were identified through a household census. Consenting individuals answer an epidemiological survey exploring risk factors (psycho-social, pesticides, diet, alcohol, and physical activity), medical history and physical and cognitive conditions; provide fasting blood, urine, and saliva samples; receive an electrocardiogram, abdominal ultrasound and bio-impedance test; and take a hand-grip strength test. These subjects will be re-interviewed after 2, 5 and 7 years. Active surveillance of health events is in place throughout the regional healthcare system. The MAUCO Bio-Bank will store 30 to 50 aliquots per subject using an NIH/NCI biorepository system for secure and anonymous linkage of samples with data. Discussion: MAUCÓs results will help design public health interventions tailored to agricultural populations in Latin America.
KW - Agricultural workers diseases
KW - Cardiovascular diseases
KW - Chronic disease/epidemiology
KW - Cohort studies
KW - Neoplasms/Epidemiology
KW - Population surveillance
KW - Prospective studies
UR - http://www.scopus.com/inward/record.url?scp=84959575267&partnerID=8YFLogxK
U2 - 10.1186/s12889-015-2454-2
DO - 10.1186/s12889-015-2454-2
M3 - Article
C2 - 26847446
AN - SCOPUS:84959575267
SN - 1471-2458
VL - 16
JO - BMC Public Health
JF - BMC Public Health
IS - 1
M1 - 122
ER -