TY - JOUR
T1 - Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia
AU - Couto, Blas
AU - Manes, Facundo
AU - Montañés, Patricia
AU - Matallana, Diana
AU - Reyes, Pablo
AU - Velasquez, Marcela
AU - Yoris, Adrián
AU - Baez, Sandra
AU - Ibáñez, Agustin
PY - 2013/8/13
Y1 - 2013/8/13
N2 - Social cognition impairments are pervasive in the frontotemporal dementias (FTD). These deficits would be triggered by (a) basic emotion and face recognition processes as well as by (b) higher level social cognition (e.g., theory of mind, ToM). Both emotional processing and social cognition impairments have been previously reported in the behavioral variant of FTD (bvFTD) and also in other versions of FTDs, including primary progressive aphasia. However, no neuroanatomic comparison between different FTD variants has been performed. We report selective behavioral impairments of face recognition, emotion recognition, and ToM in patients with bvFTD and progressive non-fluent aphasia (PNFA) when compared to controls. Voxel-based morphometry (VBM) shows a classical impairment of mainly orbitofrontal (OFC), anterior cingulate (ACC), insula and lateral temporal cortices in patients. Comparative analysis of regional gray matter related to social cognition deficits (VBM) reveals a differential pattern of fronto-insulo-temporal atrophy in bvFTD and an insulo-temporal involvement in PNFA group. Results suggest that in spite of similar social cognition impairments reported in bvFTD and PNFA, the former represents an inherent ToM affectation whereas in the PNFA these deficits could be related to more basic processes of face and emotion recognition. These results are interpreted in the frame of the fronto-insulo-temporal social context network model (SCNM).
AB - Social cognition impairments are pervasive in the frontotemporal dementias (FTD). These deficits would be triggered by (a) basic emotion and face recognition processes as well as by (b) higher level social cognition (e.g., theory of mind, ToM). Both emotional processing and social cognition impairments have been previously reported in the behavioral variant of FTD (bvFTD) and also in other versions of FTDs, including primary progressive aphasia. However, no neuroanatomic comparison between different FTD variants has been performed. We report selective behavioral impairments of face recognition, emotion recognition, and ToM in patients with bvFTD and progressive non-fluent aphasia (PNFA) when compared to controls. Voxel-based morphometry (VBM) shows a classical impairment of mainly orbitofrontal (OFC), anterior cingulate (ACC), insula and lateral temporal cortices in patients. Comparative analysis of regional gray matter related to social cognition deficits (VBM) reveals a differential pattern of fronto-insulo-temporal atrophy in bvFTD and an insulo-temporal involvement in PNFA group. Results suggest that in spite of similar social cognition impairments reported in bvFTD and PNFA, the former represents an inherent ToM affectation whereas in the PNFA these deficits could be related to more basic processes of face and emotion recognition. These results are interpreted in the frame of the fronto-insulo-temporal social context network model (SCNM).
KW - Fronto-insulo-temporal network
KW - PNFA
KW - Social context network model
KW - Theory of mind
KW - Voxel-based morphometry
KW - bvFTD
UR - http://www.scopus.com/inward/record.url?scp=84884680986&partnerID=8YFLogxK
U2 - 10.3389/fnhum.2013.00467
DO - 10.3389/fnhum.2013.00467
M3 - Article
AN - SCOPUS:84884680986
SN - 1662-5161
JO - Frontiers in Human Neuroscience
JF - Frontiers in Human Neuroscience
IS - AUG
M1 - 467
ER -