TY - JOUR
T1 - Structural Brain Differences in the Alzheimer's Disease Continuum
T2 - Insights Into the Heterogeneity From a Large Multisite Neuroimaging Consortium
AU - Alzheimer's Disease Neuroimaging Initiative
AU - Australian Imaging Biomarkers and Lifestyle flagship study of ageing
AU - Evans, Tavia E.
AU - Vilor-Tejedor, Natalia
AU - Operto, Gregory
AU - Falcon, Carles
AU - Hofman, Albert
AU - Ibáñez, Agustin
AU - Seshadari, Sudha
AU - Tan, Louis C.S.
AU - Weiner, Michael
AU - Alladi, Suverna
AU - Anazodo, Udunna
AU - Gispert, Juan Domingo
AU - Adams, Hieab H.H.
N1 - Publisher Copyright:
© 2024 Society of Biological Psychiatry
PY - 2024
Y1 - 2024
N2 - Background: Neurodegenerative diseases require collaborative, multisite research to comprehensively grasp their complex and diverse pathological progression; however, there is caution in aggregating global data due to data heterogeneity. In the current study, we investigated brain structure across stages of Alzheimer's disease (AD) and how relationships vary across sources of heterogeneity. Methods: Using 6 international datasets (N > 27,000), associations of structural neuroimaging markers were investigated in relation to the AD continuum via meta-analysis. We investigated whether associations varied across elements of magnetic resonance imaging acquisition, study design, and populations. Results: Modest differences in associations were found depending on how data were acquired; however, patterns were similar. Preliminary results suggested that neuroimaging marker–AD relationships differ across ethnic groups. Conclusions: Diversity in data offers unique insights into the neural substrate of AD; however, harmonized processing and transparency of data collection are needed. Global collaborations should embrace the inherent heterogeneity that exists in the data and quantify its contribution to research findings at the meta-analytical stage.
AB - Background: Neurodegenerative diseases require collaborative, multisite research to comprehensively grasp their complex and diverse pathological progression; however, there is caution in aggregating global data due to data heterogeneity. In the current study, we investigated brain structure across stages of Alzheimer's disease (AD) and how relationships vary across sources of heterogeneity. Methods: Using 6 international datasets (N > 27,000), associations of structural neuroimaging markers were investigated in relation to the AD continuum via meta-analysis. We investigated whether associations varied across elements of magnetic resonance imaging acquisition, study design, and populations. Results: Modest differences in associations were found depending on how data were acquired; however, patterns were similar. Preliminary results suggested that neuroimaging marker–AD relationships differ across ethnic groups. Conclusions: Diversity in data offers unique insights into the neural substrate of AD; however, harmonized processing and transparency of data collection are needed. Global collaborations should embrace the inherent heterogeneity that exists in the data and quantify its contribution to research findings at the meta-analytical stage.
KW - Alzheimer's disease
KW - Diversity
KW - Heterogeneity
KW - Imaging
KW - MRI
KW - Multisite
UR - http://www.scopus.com/inward/record.url?scp=85207701687&partnerID=8YFLogxK
U2 - 10.1016/j.bpsc.2024.07.019
DO - 10.1016/j.bpsc.2024.07.019
M3 - Article
C2 - 39084525
AN - SCOPUS:85207701687
SN - 2451-9022
JO - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
ER -