Social concepts and the cerebellum: Behavioural and functional connectivity signatures in cerebellar ataxic patients

Pamela Lopes Da Cunha, Sol Fittipaldi, Cecilia González Campo, Marcelo Kauffman, Sergio Rodríguez-Quiroga, Darío Andrés Yacovino, Agustín Ibáñez, Agustina Birba, Adolfo M. García

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Neurocognitive research on social concepts underscores their reliance on fronto-temporo-limbic regions mediating broad socio-cognitive skills. Yet, the field has neglected another structure increasingly implicated in social cognition: the cerebellum. The present exploratory study examines this link combining a novel naturalistic text paradigm, a relevant atrophy model and functional magnetic resonance imaging. Fifteen cerebellar ataxia (CA) patients with focal cerebellar atrophy and 29 matched controls listened to a social text (highlighting interpersonal events) as well as a non-social text (focused on a single person's actions), and answered comprehension questionnaires. We compared behavioural outcomes between groups and examined their association with cerebellar connectivity. CA patients showed deficits in social text comprehension and normal scores in the non-social text. Also, social text outcomes in controls selectively correlated with connectivity between the cerebellum and key regions subserving multi-modal semantics and social cognition, including the superior and medial temporal gyri, the temporal pole and the insula. Conversely, brain-behaviour associations involving the cerebellum were abolished in the patients. Thus, cerebellar structures and connections seem involved in processing social concepts evoked by naturalistic discourse. Such findings invite new theoretical and translational developments integrating social neuroscience with embodied semantics. This article is part of the theme issue 'Concepts in interaction: social engagement and inner experiences'.

Original languageEnglish
Article number20210364
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Issue number1870
StatePublished - 13 Feb 2023
Externally publishedYes


  • cerebellar ataxia
  • naturalistic texts
  • resting-state functional connectivity
  • social concepts
  • voxel-based morphometry


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