Reconstruction of Boolean Regulatory Models of Flower Development Exploiting an Evolution Strategy

Gonzalo A. Ruz, Eric Goles, Sylvain Sené

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

One of the first popular applications of Boolean networks for gene regulatory networks corresponds to the Mendoza Alvarez-Buylla network of flower development. In this paper, we consider this model and a reduced version to reconstruct synthetic threshold Boolean networks that have the same asymptotic behavior as these base models. For this, we employ an evolution strategy to search for neighboring solutions. We were able to find solutions with fewer edges as well as networks with more balanced distributions of basins of attractions. Overall, our results show the effectiveness of using evolutionary computation in this application to explore alternative solutions with desired properties.

Original languageEnglish
Title of host publication2018 IEEE Congress on Evolutionary Computation, CEC 2018 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781509060177
DOIs
StatePublished - 28 Sep 2018
Event2018 IEEE Congress on Evolutionary Computation, CEC 2018 - Rio de Janeiro, Brazil
Duration: 8 Jul 201813 Jul 2018

Publication series

Name2018 IEEE Congress on Evolutionary Computation, CEC 2018 - Proceedings

Conference

Conference2018 IEEE Congress on Evolutionary Computation, CEC 2018
Country/TerritoryBrazil
CityRio de Janeiro
Period8/07/1813/07/18

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