TY - JOUR
T1 - Rating method for dilated virchow-robin spaces on magnetic resonance imaging
AU - Adams, Hieab H.H.
AU - Cavalieri, Margherita
AU - Verhaaren, Benjamin F.J.
AU - Bos, Daniel
AU - Van Der Lugt, Aad
AU - Enzinger, Christian
AU - Vernooij, Meike W.
AU - Schmidt, Reinhold
AU - Ikram, M. Arfan
PY - 2013/6
Y1 - 2013/6
N2 - Background and Purpose-Dilated Virchow-Robin spaces are an emerging neuroimaging biomarker, but their assessment on MRI needs standardization. Methods-We developed a rating method for dilated Virchow-Robin spaces in 4 brain regions (centrum semiovale, basal ganglia, hippocampus, and mesencephalon) and tested its reliability in a total of 125 MRI scans from 2 population-based studies. Six investigators with varying levels of experience performed the ratings. Intraclass correlation coefficients were calculated to determine intra-and interrater reliability. Results-Intrarater reliability was excellent for all 4 regions (intraclass correlation coefficient, >0.8). Interrater reliability was excellent for the centrum semiovale and hippocampus (intraclass correlation coefficient, >0.8) and good for the basal ganglia and mesencephalon (intraclass correlation coefficient, 0.6-0.8). This did not differ between the cohorts or experience levels. Conclusions-We describe a reliable rating method that can facilitate pathogenic and prognostic research on dilated Virchow-Robin spaces using MRI.
AB - Background and Purpose-Dilated Virchow-Robin spaces are an emerging neuroimaging biomarker, but their assessment on MRI needs standardization. Methods-We developed a rating method for dilated Virchow-Robin spaces in 4 brain regions (centrum semiovale, basal ganglia, hippocampus, and mesencephalon) and tested its reliability in a total of 125 MRI scans from 2 population-based studies. Six investigators with varying levels of experience performed the ratings. Intraclass correlation coefficients were calculated to determine intra-and interrater reliability. Results-Intrarater reliability was excellent for all 4 regions (intraclass correlation coefficient, >0.8). Interrater reliability was excellent for the centrum semiovale and hippocampus (intraclass correlation coefficient, >0.8) and good for the basal ganglia and mesencephalon (intraclass correlation coefficient, 0.6-0.8). This did not differ between the cohorts or experience levels. Conclusions-We describe a reliable rating method that can facilitate pathogenic and prognostic research on dilated Virchow-Robin spaces using MRI.
KW - Epidemiology
KW - MRI
KW - Population-based study
KW - Virchow-Robin spaces
UR - https://www.scopus.com/pages/publications/84880168951
U2 - 10.1161/STROKEAHA.111.000620
DO - 10.1161/STROKEAHA.111.000620
M3 - Article
C2 - 23640831
AN - SCOPUS:84880168951
SN - 0039-2499
VL - 44
SP - 1732
EP - 1735
JO - Stroke
JF - Stroke
IS - 6
ER -