Rating method for dilated virchow-robin spaces on magnetic resonance imaging

Hieab H.H. Adams, Margherita Cavalieri, Benjamin F.J. Verhaaren, Daniel Bos, Aad Van Der Lugt, Christian Enzinger, Meike W. Vernooij, Reinhold Schmidt, M. Arfan Ikram

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Background and Purpose-Dilated Virchow-Robin spaces are an emerging neuroimaging biomarker, but their assessment on MRI needs standardization. Methods-We developed a rating method for dilated Virchow-Robin spaces in 4 brain regions (centrum semiovale, basal ganglia, hippocampus, and mesencephalon) and tested its reliability in a total of 125 MRI scans from 2 population-based studies. Six investigators with varying levels of experience performed the ratings. Intraclass correlation coefficients were calculated to determine intra-and interrater reliability. Results-Intrarater reliability was excellent for all 4 regions (intraclass correlation coefficient, >0.8). Interrater reliability was excellent for the centrum semiovale and hippocampus (intraclass correlation coefficient, >0.8) and good for the basal ganglia and mesencephalon (intraclass correlation coefficient, 0.6-0.8). This did not differ between the cohorts or experience levels. Conclusions-We describe a reliable rating method that can facilitate pathogenic and prognostic research on dilated Virchow-Robin spaces using MRI.

Original languageEnglish
Pages (from-to)1732-1735
Number of pages4
Issue number6
StatePublished - Jun 2013
Externally publishedYes


  • Epidemiology
  • MRI
  • Population-based study
  • Virchow-Robin spaces


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