PEG-stabilized core-shell surface-imprinted nanoparticles

Ewa Moczko, Antonio Guerreiro, Elena Piletska, Sergey Piletsky

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Here we present a simple technique to produce target-specific molecularly imprinted polymeric nanoparticles (MIP NPs) and their surface modification in order to prevent the aggregation process that is ever-present in most nanomaterial suspensions/dispersions. Specifically, we studied the influence of surface modification of MIP NPs with polymerizable poly(ethylene glycol) on their degree of stability in water, in phosphate buffer, and in the presence of serum proteins. Grafting a polymer shell on the surface of nanoparticles decreases the surface energy, enhances the polarity, and as a result improves the dispersibility, storage, and colloidal stability as compared to those of core (unmodified) particles. Because of the unique solid-phase approach used for synthesis, the binding sites of MIP NPs are protected during grafting, and the recognition properties of nanoparticles are not affected. These results are significant for developing nanomaterials with selective molecular recognition, increased biocompatibility, and stability in solution. Materials synthesized this way have the potential to be used in a variety of technological fields, including in vivo applications such as drug delivery and imaging.

Original languageEnglish
Pages (from-to)9891-9896
Number of pages6
JournalLangmuir
Volume29
Issue number31
DOIs
StatePublished - 6 Aug 2013
Externally publishedYes

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