TY - JOUR
T1 - Osteochondroma after Hematopoietic Stem Cell Transplantation in Childhood. An Italian Study on Behalf of the AIEOP-HSCT Group
AU - Faraci, Maura
AU - Bagnasco, Francesca
AU - Corti, Paola
AU - Messina, Chiara
AU - Fagioli, Franca
AU - Podda, Marta
AU - Prete, Arcangelo
AU - Caselli, Desirè
AU - Lanino, Edoardo
AU - Dini, Giorgio
AU - Rondelli, Roberto
AU - Haupt, Riccardo
PY - 2009/10
Y1 - 2009/10
N2 - A retrospective study was conducted among Italian children treated with hematopoietic stem cell transplant (HSCT) to evaluate the incidence and risk factors in the development of osteochondroma (OC). OC occurred in 27 patients who received autologous or allogeneic HSCT. The estimated 5-, 10-, and 15-year cumulative risk of developing OC was 0.5%, 3.2%, and 6.1%, respectively. Analysis of cumulative risk stratified by the various risk factors revealed that male sex (P = .026), autologous HSCT (P = .001), age at HSCT (≤3 years) (P < .0001), and total body irradiation (TBI) (P < .0001) significantly affected the risk of OC. Multivariate analysis, restricted only to tumor types with at least 1 case of OC, showed that earlier age at HSCT (P = .0004) and TBI (P < .0001) were the only factors that were significantly associated with OC.
AB - A retrospective study was conducted among Italian children treated with hematopoietic stem cell transplant (HSCT) to evaluate the incidence and risk factors in the development of osteochondroma (OC). OC occurred in 27 patients who received autologous or allogeneic HSCT. The estimated 5-, 10-, and 15-year cumulative risk of developing OC was 0.5%, 3.2%, and 6.1%, respectively. Analysis of cumulative risk stratified by the various risk factors revealed that male sex (P = .026), autologous HSCT (P = .001), age at HSCT (≤3 years) (P < .0001), and total body irradiation (TBI) (P < .0001) significantly affected the risk of OC. Multivariate analysis, restricted only to tumor types with at least 1 case of OC, showed that earlier age at HSCT (P = .0004) and TBI (P < .0001) were the only factors that were significantly associated with OC.
KW - Autologous HSCT
KW - Osteochondroma
KW - Total-body irradiation
KW - Younger age
UR - http://www.scopus.com/inward/record.url?scp=69749114720&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2009.06.003
DO - 10.1016/j.bbmt.2009.06.003
M3 - Article
C2 - 19747635
AN - SCOPUS:69749114720
SN - 1083-8791
VL - 15
SP - 1271
EP - 1276
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 10
ER -