Number of years with type 2 diabetes is associated with cognitive impairment in Chilean older adults: A cross-sectional study

Agnieszka Bozanic, Fanny Petermann-Rocha, Heather Waddell, Solange Parra-Soto, Carla Cuevas, Claire Richardson, María Adela Martínez-Sanguinetti, Ana María Leiva-Ordoñez, Gabriela Nazar, Claudia Troncoso, Lorena Mardones, Marcelo Villagrán, Miquel Martorell, Eva Ariño Mateo, Carolina Ochoa-Rosales, Ximena Diaz-Martinez, Natalia Ulloa, Carlos Celis-Morales

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Introduction: The average life expectancy, as well as the prevalence of Type 2 diabetes (T2D), is increasing worldwide. Population-based studies have demonstrated that the duration of T2D has been associated with cognitive impairment. However, despite the high prevalence of T2D and cognitive impairment in Chile, the association between years with T2D and suspicion of cognitive impairment has not yet been investigated. The objective of this study was to investigate the association between duration of T2D and suspicion of cognitive impairment in Chilean older adults. Material and Methods: 1,040 older adults aged ≥60 years from the Chilean National Health Survey (2009-2010) were included. Suspicion of cognitive impairment was assessed by the abbreviated Mini-Mental State Examination (MMSE). The number of years with T2D was self-reported and categorised into four groups. Poisson Regression analysis was used to assess the association between altered MMSE and the number of years with DM2, adjusted by potential confounders including socio-demographic, lifestyle, adiposity and health-related factors. Results: When the analyses were adjusted for socio-demographic factors, people who had T2D for 15 to 24 and ≥25 years had 2.2-times (95%CI: 1.07; 3.33) and 5.8-times (95%CI: 3.81; 11.0) higher relative risk (RR) of cognitive impairment, compared to those without T2D. When the analyses were additionally adjusted for lifestyle and health-related covariates, the RR for cognitive impairment was 1.76-times (95%CI: 1.02; 2.50) and 4.54-times (95%CI: 2.70; 6.38) higher for those who had T2D for 14-24 years and ≥25 years, respectively. Conclusions: Number of years with T2D was associated with suspicion of cognitive impairment. A longer duration of T2D was associated with a higher likelihood of cognitive impairment in the Chilean older population, independently of confounder factors included in the study.

Original languageEnglish
Pages (from-to)316-325
Number of pages10
JournalRevista Espanola de Nutricion Humana y Dietetica
Issue number3
StatePublished - Sep 2021
Externally publishedYes


  • Aging
  • Cognitive Dysfunction
  • Diabetes Mellitus, Type 2


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