@article{5c3fa654db9943feb38ed042371f1cf8,
title = "New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry",
abstract = "Body-mass index (BMI) is a hallmark of adiposity. In contrast with adulthood, the genetic architecture of BMI during childhood is poorly understood. The few genome-wide association studies (GWAS) on children have been performed almost exclusively in Europeans and at single ages. We performed cross-sectional and longitudinal GWAS for BMI-related traits on 904 admixed children with mostly Mapuche Native American and European ancestries. We found regulatory variants of the immune gene HLA-DQB3 strongly associated with BMI at 1.5−2.5 years old. A variant in the sex-determining gene DMRT1 was associated with the age at adiposity rebound (Age-AR) in girls (P=9.8×10−9). BMI was significantly higher in Mapuche than in Europeans between 5.5 and 16.5 years old. Finally, Age-AR was significantly lower (P=0.004) by 1.94 years and BMI at AR was significantly higher (P=0.04) by 1.2 kg/m2, in Mapuche children compared with Europeans.",
keywords = "Genomics, Health sciences, Human genetics",
author = "Lucas Vicu{\~n}a and Esteban Barrientos and Tom{\'a}s Norambuena and Danilo Alvares and Gana, {Juan Cristobal} and Valeria Leiva-Yamaguchi and Cristian Meza and Santos, {Jos{\'e} L.} and Veronica Mericq and Ana Pereira and Susana Eyheramendy",
note = "Funding Information: This work was supported by the Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT) [1200146 to S.E. L.V. and E.B.; 1190346 to V.M.; 1150416 and 1150486 to JL.S. 1190801 to C.M. ]. S.E. T.N. and L.V. were additionally supported by the Instituto Milenio de Investigaci{\'o}n Sobre los Fundamentos de los Datos (IMFD). D.A. was supported by the UKRIMedical Research Council, grant number MC _UU_ 00002/5. Informed consent from participants was obtained from parents or guardians. Children agreed to participate when they turned 7 years old. This study was approved by the Scientific Ethics Committees of Instituto deNutrici{\'o}n y Tecnolog{\'i}a en Alimentos (INTA) and Pontificia Universidad Cat{\'o}lica deChile. S.E. conceived the project. S.E. and L.V. designed experiments. E.B. L.V. T.N. C.M. D.A. and V.L. analyzed the data. A.P. and V.M. collected phenotype data. S.E. JL.S. and JC.G. raised funds for the genotyping data. L.V. S.E. and E.B. wrote the manuscript. All authors critically reviewed and accepted the final version. The authors declare that there is no conflict of interest. The current affiliation of L.V. is the Department of Medicine, Genetics Section, University of Chicago, Chicago, USA. Funding Information: This work was supported by the Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT) [ 1200146 to S.E., L.V. and E.B.; 1190346 to V.M.; 1150416 and 1150486 to JL.S., 1190801 to C.M. ]. S.E., T.N. and L.V. were additionally supported by the Instituto Milenio de Investigaci{\'o}n Sobre los Fundamentos de los Datos ( IMFD ). D.A. was supported by the UKRIMedical Research Council , grant number MC _UU_ 00002/5 . Informed consent from participants was obtained from parents or guardians. Children agreed to participate when they turned 7 years old. This study was approved by the Scientific Ethics Committees of Instituto deNutrici{\'o}n y Tecnolog{\'i}a en Alimentos (INTA) and Pontificia Universidad Cat{\'o}lica deChile. Publisher Copyright: {\textcopyright} 2023 The Author(s)",
year = "2023",
month = feb,
day = "17",
doi = "10.1016/j.isci.2023.106091",
language = "English",
volume = "26",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "2",
}
