@article{51859501e54449e987b1680287af71a4,
title = "Nanoparticles of 4,7-dichloro-2-quinolinemethylacrylate-based copolymers and their potential cytotoxic activity on human breast carcinoma cells",
abstract = " In this article, an improved synthesis strategy of the potent anticancer compound 4,7-dichloro-2-quinolinemethanol (QM) and its acrylate ester 4,7-dichloro-2-quinolinemethylacrylate (AQM) are described. AQM is copolymerized using free-radical polymerization with N-vinyl-2-pyrrolidone (VP) and the copolymers obtained from different molar ratios of monomers are subjected to nanoprecipitation to produce suspensions of nanoparticles (NPs) in phosphate buffered saline (PBS). The smallest and stable NPs are prepared with the AQM-VP copolymers 45:55 and 40:60 (118.9 and 128.7 nm in diameter, respectively) at 1 mg mL −1 , and along with AQM and QM, are evaluated for their cytotoxic activity on MDA-MB-453 breast carcinoma cells using MTT bioassay. AQM and QM are highly cytotoxic (IC 50 : 19 and 41 μM, respectively); however, the NPs are not cytotoxic in the range of the assayed concentrations. These results contribute to the search for new polymeric NPs with potential application as QM delivery systems for the treatment of cancer or other diseases treatable with QM.",
keywords = "biomedical applications, copolymers, nanoparticles, radical polymerization, self-assembly",
author = "Hern{\'a}n Valle and Raquel Palao-Suay and Aguilar, {Mar{\'i}a Rosa} and Rom{\'a}n, {Julio San} and Jos{\'e} Becerra and Bernab{\'e} Rivas and Mangalaraja, {Ramalinga Viswanathan}",
note = "Funding Information: H. Valle and R.V. Mangalaraja acknowledge funding support from the Comisi{\'o}n Nacional de Ciencia y Tecnolog{\'i}a (CONI-CYT), Chile, through the projects CONICYT/FONDECYT postdoctoral N°3160296 and CONICYT PIA/APOYO CCTE AFB170007, respectively. R. Palao-Suay, M.R. Aguilar and J.S. Rom{\'a}n acknowledge financial support from the Spanish Ministry of Economy and Competitiveness, through the project MAT2017-84277-R. Authors also thank Dr. Mar Fern{\'a}ndez and Rosa Ana Ram{\'i}rez for their help in cell culture. Funding Information: H. Valle and R.V. Mangalaraja acknowledge funding support from the Comisi?n Nacional de Ciencia y Tecnolog?a (CONICYT), Chile, through the projects CONICYT/FONDECYT postdoctoral N?3160296 and CONICYT PIA/APOYO CCTE AFB170007, respectively. R. Palao-Suay, M.R. Aguilar and J.S. Rom?n acknowledge financial support from the Spanish Ministry of Economy and Competitiveness, through the project MAT2017-84277-R. Authors also thank Dr. Mar Fern?ndez and Rosa Ana Ram?rez for their help in cell culture. Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",
year = "2019",
month = may,
day = "20",
doi = "10.1002/app.47545",
language = "English",
volume = "136",
journal = "Journal of Applied Polymer Science",
issn = "0021-8995",
publisher = "John Wiley & Sons Inc.",
number = "20",
}