More than words: Social cognition across variants of primary progressive aphasia

Sol Fittipaldi, Agustín Ibanez, Sandra Baez, Facundo Manes, Lucas Sedeno, Adolfo M. Garcia

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

Although primary progressive aphasia (PPA) is clinically typified by linguistic impairments, emerging evidence highlights the presence of early deficits in social cognition. This review systematically describes the latter patterns, specifying their relation to the characteristic linguistic dysfunctions and atrophy patterns of non-fluent, semantic, and logopenic variants of the disease (nfvPPA, svPPA, and lvPPA, respectively), relative to closely related dementia types. Whereas the evidence on lvPPA proves scant, studies on nfvPPA and svPPA patients show consistent deficits in emotion recognition, theory of mind, and empathy. Notably, these seem to be intertwined with language impairments in nfvPPA, but they prove primary and independent of language disturbances in svPPA. Also, only the profile of svPPA resembles that of behavioral variant frontotemporal dementia, probably reflecting the overlap of fronto-temporal disruptions in both conditions. In short, the neurocognitive relationship between linguistic and socio-cognitive deficits cannot be precisely predicated for PPA as a whole; instead, specific links must be acknowledged in each variant. These emergent patterns pave the way for fruitful dimensional research in the field.

Original languageEnglish
Pages (from-to)263-284
Number of pages22
JournalNeuroscience and Biobehavioral Reviews
Volume100
DOIs
StatePublished - May 2019
Externally publishedYes

Keywords

  • Emotion recognition
  • Empathy
  • Logopenic variant primary progressive aphasia
  • Neural biomarkers
  • Non-fluent variant primary progressive aphasia
  • Primary progressive aphasia
  • Semantic variant primary progressive aphasia
  • Social cognition
  • Theory of mind

Fingerprint

Dive into the research topics of 'More than words: Social cognition across variants of primary progressive aphasia'. Together they form a unique fingerprint.

Cite this