TY - JOUR
T1 - Migraine, inflammatory bowel disease and celiac disease
T2 - A Mendelian randomization study
AU - The International Headache Genetics Consortium
AU - Welander, Nike Zoe
AU - Rukh, Gull
AU - Rask-Andersen, Mathias
AU - Harder, Aster V.E.
AU - Gormley, Padhraig
AU - Anttila, Verneri
AU - Winsvold, Bendik S.
AU - Palta, Priit
AU - Esko, Tonu
AU - Pers, Tune H.
AU - Farh, Kai How
AU - Cuenca-Leon, Ester
AU - Muona, Mikko
AU - Furlotte, Nicholas A.
AU - Kurth, Tobias
AU - Ingason, Andres
AU - McMahon, George
AU - Ligthart, Lannie
AU - Terwindt, Gisela M.
AU - Kallela, Mikko
AU - Freilinger, Tobias M.
AU - Ran, Caroline
AU - Gordon, Scott G.
AU - Stam, Anine H.
AU - Steinberg, Stacy
AU - Borck, Guntram
AU - Koiranen, Markku
AU - Quaye, Lydia
AU - Adams, Hieab H.H.
AU - Lehtimäki, Terho
AU - Sarin, Antti Pekka
AU - Wedenoja, Juho
AU - Hinds, David A.
AU - Buring, Julie E.
AU - Schürks, Markus
AU - Ridker, Paul M.
AU - Hrafnsdottir, Maria Gudlaug
AU - Stefansson, Hreinn
AU - Ring, Susan M.
AU - Hottenga, Jouke Jan
AU - Penninx, Brenda W.J.H.
AU - Färkkilä, Markus
AU - Artto, Ville
AU - Kaunisto, Mari
AU - Vepsäläinen, Salli
AU - Malik, Rainer
AU - Heath, Andrew C.
AU - Madden, Pamela A.F.
AU - Martin, Nicholas G.
AU - Montgomery, Grant W.
N1 - Publisher Copyright:
© 2023 The Authors. Headache: The Journal of Head and Face Pain published by Wiley Periodicals LLC on behalf of American Headache Society.
PY - 2023/5
Y1 - 2023/5
N2 - Objective: To assess whether migraine may be genetically and/or causally associated with inflammatory bowel disease (IBD) or celiac disease. Background: Migraine has been linked to IBD and celiac disease in observational studies, but whether this link may be explained by a shared genetic basis or could be causal has not been established. The presence of a causal association could be clinically relevant, as treating one of these medical conditions might mitigate the symptoms of a causally linked condition. Methods: Linkage disequilibrium score regression and two-sample bidirectional Mendelian randomization analyses were performed using summary statistics from cohort-based genome-wide association studies of migraine (59,674 cases; 316,078 controls), IBD (25,042 cases; 34,915 controls) and celiac disease (11,812 or 4533 cases; 11,837 or 10,750 controls). Migraine with and without aura were analyzed separately, as were the two IBD subtypes Crohn's disease and ulcerative colitis. Positive control analyses and conventional Mendelian randomization sensitivity analyses were performed. Results: Migraine was not genetically correlated with IBD or celiac disease. No evidence was observed for IBD (odds ratio [OR] 1.00, 95% confidence interval [CI] 0.99–1.02, p = 0.703) or celiac disease (OR 1.00, 95% CI 0.99–1.02, p = 0.912) causing migraine or migraine causing either IBD (OR 1.08, 95% CI 0.96–1.22, p = 0.181) or celiac disease (OR 1.08, 95% CI 0.79–1.48, p = 0.614) when all participants with migraine were analyzed jointly. There was some indication of a causal association between celiac disease and migraine with aura (OR 1.04, 95% CI 1.00–1.08, p = 0.045), between celiac disease and migraine without aura (OR 0.95, 95% CI 0.92–0.99, p = 0.006), as well as between migraine without aura and ulcerative colitis (OR 1.15, 95% CI 1.02–1.29, p = 0.025). However, the results were not significant after multiple testing correction. Conclusions: We found no evidence of a shared genetic basis or of a causal association between migraine and either IBD or celiac disease, although we obtained some indications of causal associations with migraine subtypes.
AB - Objective: To assess whether migraine may be genetically and/or causally associated with inflammatory bowel disease (IBD) or celiac disease. Background: Migraine has been linked to IBD and celiac disease in observational studies, but whether this link may be explained by a shared genetic basis or could be causal has not been established. The presence of a causal association could be clinically relevant, as treating one of these medical conditions might mitigate the symptoms of a causally linked condition. Methods: Linkage disequilibrium score regression and two-sample bidirectional Mendelian randomization analyses were performed using summary statistics from cohort-based genome-wide association studies of migraine (59,674 cases; 316,078 controls), IBD (25,042 cases; 34,915 controls) and celiac disease (11,812 or 4533 cases; 11,837 or 10,750 controls). Migraine with and without aura were analyzed separately, as were the two IBD subtypes Crohn's disease and ulcerative colitis. Positive control analyses and conventional Mendelian randomization sensitivity analyses were performed. Results: Migraine was not genetically correlated with IBD or celiac disease. No evidence was observed for IBD (odds ratio [OR] 1.00, 95% confidence interval [CI] 0.99–1.02, p = 0.703) or celiac disease (OR 1.00, 95% CI 0.99–1.02, p = 0.912) causing migraine or migraine causing either IBD (OR 1.08, 95% CI 0.96–1.22, p = 0.181) or celiac disease (OR 1.08, 95% CI 0.79–1.48, p = 0.614) when all participants with migraine were analyzed jointly. There was some indication of a causal association between celiac disease and migraine with aura (OR 1.04, 95% CI 1.00–1.08, p = 0.045), between celiac disease and migraine without aura (OR 0.95, 95% CI 0.92–0.99, p = 0.006), as well as between migraine without aura and ulcerative colitis (OR 1.15, 95% CI 1.02–1.29, p = 0.025). However, the results were not significant after multiple testing correction. Conclusions: We found no evidence of a shared genetic basis or of a causal association between migraine and either IBD or celiac disease, although we obtained some indications of causal associations with migraine subtypes.
KW - Mendelian randomization
KW - celiac disease
KW - gastrointestinal disease
KW - genetic correlation
KW - inflammatory bowel disease
KW - migraine
UR - http://www.scopus.com/inward/record.url?scp=85147309629&partnerID=8YFLogxK
U2 - 10.1111/head.14470
DO - 10.1111/head.14470
M3 - Article
C2 - 36705326
AN - SCOPUS:85147309629
SN - 0017-8748
VL - 63
SP - 642
EP - 651
JO - Headache
JF - Headache
IS - 5
ER -