Microporosity clustering assessment in calcium phosphate bioceramic particles

Raúl Vallejos Baier, Isabel Benjumeda Wijnhoven, Víctor Irribarra Del Valle, Carola Millán Giovanetti, Juan F. Vivanco

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


There has been an increase in the application of different biomaterials to repair hard tissues. Within these biomaterials, calcium phosphate (CaP) bioceramics are suitable candidates, since they can be biocompatible, biodegradable, osteoinductive, and osteoconductive. Moreover, during sintering, bioceramic materials are prone to form micropores and undergo changes in their surface topographical features, which influence cellular physiology and bone ingrowth. In this study, five geometrical properties from the surface of CaP bioceramic particles and their micropores were analyzed by data mining techniques, driven by the research question: what are the geometrical properties of individual micropores in a CaP bioceramic, and how do they relate to each other? The analysis not only shows that it is feasible to determine the existence of micropore clusters, but also to quantify their geometrical properties. As a result, these CaP bioceramic particles present three groups of micropore clusters distinctive by their geometrical properties. Consequently, this new methodological clustering assessment can be applied to advance the knowledge about CaP bioceramics and their role in bone tissue engineering.

Original languageEnglish
Article number281
JournalFrontiers in Bioengineering and Biotechnology
Issue numberOCT
StatePublished - 2019
Externally publishedYes


  • Bioceramic particle
  • Calcium phosphate
  • Data mining
  • K-means clustering
  • Microporosity


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