Mechanical, material, and antimicrobial properties of acrylic bone cement impregnated with silver nanoparticles

Josh Slane, Juan Vivanco, Warren Rose, Heidi Lynn Ploeg, Matthew Squire

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


Prosthetic joint infection is one of the most serious complications that can lead to failure of a total joint replacement. Recently, the rise of multidrug resistant bacteria has substantially reduced the efficacy of antibiotics that are typically incorporated into acrylic bone cement. Silver nanoparticles (AgNPs) are an attractive alternative to traditional antibiotics resulting from their broad-spectrum antimicrobial activity and low bacterial resistance. The purpose of this study, therefore, was to incorporate metallic silver nanoparticles into acrylic bone cement and quantify the effects on the cement's mechanical, material and antimicrobial properties. AgNPs at three loading ratios (0.25, 0.5, and 1.0% wt/wt) were incorporated into a commercial bone cement using a probe sonication technique. The resulting cements demonstrated mechanical and material properties that were not substantially different from the standard cement. Testing against Staphylococcus aureus and Staphylococcus epidermidis using Kirby-Bauer and time-kill assays demonstrated no antimicrobial activity against planktonic bacteria. In contrast, cements modified with AgNPs significantly reduced biofilm formation on the surface of the cement. These results indicate that AgNP-loaded cement is of high potential for use in primary arthroplasty where prevention of bacterial surface colonization is vital.

Original languageEnglish
Pages (from-to)188-196
Number of pages9
JournalMaterials Science and Engineering C
StatePublished - 1 Dec 2015
Externally publishedYes


  • Antimicrobial
  • Bone cement
  • Infection-
  • Mechanical properties
  • Nanoparticles


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