TY - JOUR
T1 - Maturational time course of the envelope following response to amplitude-modulated acoustic signals in rats
AU - Prado-Gutierrez, Pavel
AU - Mijares, Eleina
AU - Savio, Guillermo
AU - Borrego, Mayelin
AU - Martínez-Montes, Eduardo
AU - Torres, Alejandro
PY - 2012/4
Y1 - 2012/4
N2 - Objective: The maturation pattern of the envelope following response (EFR) was described using rats as an experimental model. Design: EFRs were recorded in animals at different postnatal ages (15, 20, 25, 35, and 70 postnatal days) in response to broadband noise (BBN) and tones of 8000 and 4000 Hz modulated in amplitude using a continuous sweep of modulation frequencies. Responses were analysed in the 90-190 Hz modulation frequency (MF) range. Study sample: Forty individuals (eight individuals for each age bracket) were included in the present study. Results: During maturation, the MF at which the maximum amplitude was obtained (BMF, best modulation frequency) shifted to higher values when animals were stimulated with tones. At the same time, the amplitude of the response at the BMF increased. For every group of animals, the amplitude of the response continuously decreased for MFs higher than the BMF. However, less steep decreases of amplitude were obtained as animals became adults. Conclusions: These results provide normative data regarding the maturation of the EFR in rats. They provide information for the development of predictor models to estimate the temporal resolution of the auditory system during maturation.
AB - Objective: The maturation pattern of the envelope following response (EFR) was described using rats as an experimental model. Design: EFRs were recorded in animals at different postnatal ages (15, 20, 25, 35, and 70 postnatal days) in response to broadband noise (BBN) and tones of 8000 and 4000 Hz modulated in amplitude using a continuous sweep of modulation frequencies. Responses were analysed in the 90-190 Hz modulation frequency (MF) range. Study sample: Forty individuals (eight individuals for each age bracket) were included in the present study. Results: During maturation, the MF at which the maximum amplitude was obtained (BMF, best modulation frequency) shifted to higher values when animals were stimulated with tones. At the same time, the amplitude of the response at the BMF increased. For every group of animals, the amplitude of the response continuously decreased for MFs higher than the BMF. However, less steep decreases of amplitude were obtained as animals became adults. Conclusions: These results provide normative data regarding the maturation of the EFR in rats. They provide information for the development of predictor models to estimate the temporal resolution of the auditory system during maturation.
KW - Auditory temporal processing
KW - Envelope following response
KW - Maturation
KW - Rats
KW - Temporal modulation transfer function
UR - http://www.scopus.com/inward/record.url?scp=84858263015&partnerID=8YFLogxK
U2 - 10.3109/14992027.2011.639812
DO - 10.3109/14992027.2011.639812
M3 - Article
C2 - 22176306
AN - SCOPUS:84858263015
SN - 1499-2027
VL - 51
SP - 309
EP - 316
JO - International Journal of Audiology
JF - International Journal of Audiology
IS - 4
ER -