Introducing MINA - The molecularly imprinted nanoparticle assay

Roman V. Shutov; Antonio Guerreiro; Ewa Moczko; Isabel Perez De Vargas-Sansalvador; Iva Chianella; Michael J. Whitcombe; Sergey A. Piletsky

doi:10.1002/smll.201301996

Introducing MINA - The molecularly imprinted nanoparticle assay

Roman V. Shutov, Antonio Guerreiro, Ewa Moczko, Isabel Perez De Vargas-Sansalvador, Iva Chianella, Michael J. Whitcombe, Sergey A. Piletsky

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

A new ELISA- (enzyme-linked immunosorbent assay)-like assay is demonstrated in which no elements of biological origin are used for molecular recognition or signaling. Composite imprinted nanoparticles that contain a catalytic core and which are synthesized by using a solid-phase approach can simultaneously act as recognition/signaling elements, and be used with minimal modifications to standard assay protocols. This assay provides a new route towards replacement of unstable biomolecules in immunoassays.

Original language	English
Pages (from-to)	1086-1089
Number of pages	4
Journal	Small
Volume	10
Issue number	6
DOIs	https://doi.org/10.1002/smll.201301996
State	Published - 26 Mar 2014
Externally published	Yes

Keywords

core-shell materials
molecular imprinting
peroxidases
solid-phase synthesis

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10.1002/smll.201301996

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abstract = "A new ELISA- (enzyme-linked immunosorbent assay)-like assay is demonstrated in which no elements of biological origin are used for molecular recognition or signaling. Composite imprinted nanoparticles that contain a catalytic core and which are synthesized by using a solid-phase approach can simultaneously act as recognition/signaling elements, and be used with minimal modifications to standard assay protocols. This assay provides a new route towards replacement of unstable biomolecules in immunoassays.",

keywords = "core-shell materials, molecular imprinting, peroxidases, solid-phase synthesis",

author = "Shutov, {Roman V.} and Antonio Guerreiro and Ewa Moczko and {De Vargas-Sansalvador}, {Isabel Perez} and Iva Chianella and Whitcombe, {Michael J.} and Piletsky, {Sergey A.}",

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AU - Shutov, Roman V.

AU - Guerreiro, Antonio

AU - Moczko, Ewa

AU - De Vargas-Sansalvador, Isabel Perez

AU - Chianella, Iva

AU - Whitcombe, Michael J.

AU - Piletsky, Sergey A.

PY - 2014/3/26

Y1 - 2014/3/26

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AB - A new ELISA- (enzyme-linked immunosorbent assay)-like assay is demonstrated in which no elements of biological origin are used for molecular recognition or signaling. Composite imprinted nanoparticles that contain a catalytic core and which are synthesized by using a solid-phase approach can simultaneously act as recognition/signaling elements, and be used with minimal modifications to standard assay protocols. This assay provides a new route towards replacement of unstable biomolecules in immunoassays.

KW - core-shell materials

KW - molecular imprinting

KW - peroxidases

KW - solid-phase synthesis

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JO - Small

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Introducing MINA - The molecularly imprinted nanoparticle assay

Abstract

Keywords

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