Introducing MINA - The molecularly imprinted nanoparticle assay

Roman V. Shutov, Antonio Guerreiro, Ewa Moczko, Isabel Perez De Vargas-Sansalvador, Iva Chianella, Michael J. Whitcombe, Sergey A. Piletsky

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

A new ELISA- (enzyme-linked immunosorbent assay)-like assay is demonstrated in which no elements of biological origin are used for molecular recognition or signaling. Composite imprinted nanoparticles that contain a catalytic core and which are synthesized by using a solid-phase approach can simultaneously act as recognition/signaling elements, and be used with minimal modifications to standard assay protocols. This assay provides a new route towards replacement of unstable biomolecules in immunoassays.

Original languageEnglish
Pages (from-to)1086-1089
Number of pages4
JournalSmall
Volume10
Issue number6
DOIs
StatePublished - 26 Mar 2014
Externally publishedYes

Keywords

  • core-shell materials
  • molecular imprinting
  • peroxidases
  • solid-phase synthesis

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