TY - JOUR
T1 - Insights into pathophysiology, biomarkers, and therapeutics in tauopathies
T2 - Proceedings of the Tau2024 Global Conference
AU - Frost, Bess
AU - Rowe, James B.
AU - Akinyemi, Rufus O.
AU - Abisambra, Jose F.
AU - Ashton, Nicholas J.
AU - Brendel, Matthias
AU - Buée, Luc
AU - Butler, David
AU - Carrillo, Maria C.
AU - Chung, Peter
AU - Clelland, Claire D.
AU - DeVos, Sarah L.
AU - Diaz, Kristophe
AU - Edelmayer, Rebecca M.
AU - Elahi, Fanny M.
AU - Ellajosyula, Ratnavalli
AU - Ewen, Colin
AU - Fontana, Igor Camargo
AU - Galas, Marie Christine
AU - Hansson, Oskar
AU - Höglinger, Günter
AU - Horie, Kanta
AU - Ibanez, Agustín
AU - Jacobs, Linde
AU - Maina, Mahmoud B.
AU - Malpetti, Maura
AU - McDade, Eric
AU - McEwan, Will
AU - Montoliu-Gaya, Laia
AU - Mummery, Catherine J.
AU - Orr, Miranda E.
AU - Rohrer, Jonathan D.
AU - Rommel, Amy
AU - Sastre, Carlos
AU - Spires-Jones, Tara L.
AU - Tee, Boon Lead
AU - Viney, Tim J.
AU - Walker, Jamie M.
AU - Wegmann, Susanne
AU - Wildsmith, Kristin
AU - Yadav, Ravi
AU - Mahinrad, Simin
AU - Sexton, Claire
N1 - Publisher Copyright:
© 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2025/5
Y1 - 2025/5
N2 - Recent years have seen major advances in tau-associated brain disorders through interdisciplinary research spanning molecular biology, neuroimaging, clinical trials, and therapeutic development. The Tau2024 Global Conference, hosted by the Alzheimer's Association, CurePSP, and Rainwater Charitable Foundation, showcased these efforts by bringing together researchers and experts worldwide to discuss the latest advancements in tau research. The conference aimed to attract talent and funding to study tauopathies, particularly among early-career researchers, and to foster interdisciplinary alignment and collaboration around challenges in tau research. In this manuscript, we summarize proceedings of the Tau2024 Global Conference, covering a wide range of topics, including lived experiences of individuals with genetic forms of tauopathies, global perspectives on tauopathies, and molecular mechanisms, brain microenvironments, biomarker developments, clinical trials, and therapeutic approaches to tauopathies. Through international, collaborative efforts, innovative research, and a commitment to inclusivity, researchers worldwide have demonstrated transformative breakthroughs toward diagnosing, treating, and, ultimately, preventing tau-related diseases. Highlights: The Tau2024 Global Conference presented updates and advances in tau research. Blood-based biomarkers offer specificity and longitudinal monitoring capabilities. There are a range of targetable mechanisms in the cascade of pathogenesis. International collaboration is vital to address disparities in tauopathies.
AB - Recent years have seen major advances in tau-associated brain disorders through interdisciplinary research spanning molecular biology, neuroimaging, clinical trials, and therapeutic development. The Tau2024 Global Conference, hosted by the Alzheimer's Association, CurePSP, and Rainwater Charitable Foundation, showcased these efforts by bringing together researchers and experts worldwide to discuss the latest advancements in tau research. The conference aimed to attract talent and funding to study tauopathies, particularly among early-career researchers, and to foster interdisciplinary alignment and collaboration around challenges in tau research. In this manuscript, we summarize proceedings of the Tau2024 Global Conference, covering a wide range of topics, including lived experiences of individuals with genetic forms of tauopathies, global perspectives on tauopathies, and molecular mechanisms, brain microenvironments, biomarker developments, clinical trials, and therapeutic approaches to tauopathies. Through international, collaborative efforts, innovative research, and a commitment to inclusivity, researchers worldwide have demonstrated transformative breakthroughs toward diagnosing, treating, and, ultimately, preventing tau-related diseases. Highlights: The Tau2024 Global Conference presented updates and advances in tau research. Blood-based biomarkers offer specificity and longitudinal monitoring capabilities. There are a range of targetable mechanisms in the cascade of pathogenesis. International collaboration is vital to address disparities in tauopathies.
KW - Alzheimer's disease
KW - neurodegenerative disease
KW - tau disorder
KW - tau protein
KW - tauopathies
UR - https://www.scopus.com/pages/publications/105006898800
U2 - 10.1002/alz.70078
DO - 10.1002/alz.70078
M3 - Review article
C2 - 40437880
AN - SCOPUS:105006898800
SN - 1552-5260
VL - 21
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 5
M1 - e70078
ER -
