Hematological, biochemical, respiratory, cardiovascular and electroneurophysiological parameters in African green monkeys (Cercopithecus aethiops sabaeus). Its use in non-clinical toxicological studies

Angel Casacó, Irene Beausoleil, Bárbara Gonzalez, Patricia Luaces, Avelina León, María E. Arteaga, Pavel Prado, Valia Rodríguez, Aylén Pérez, Grisel Guevara, Ana M. Bada, Nuris Ledón, Dasha Fuentes, Consuelo González, Osvaldo Hernandez, Romy Orphee, Diuris Blanco, Miriam García-Osuma, Alcides Ballester-Labrada

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: The purpose of this study is to better characterize the hematological, biochemical, respiratory, cardiovascular and electroneurophysiological parameters in young adult Cercopithecus aethiops sabaeus of both sexes. The rhesus and cynomolgus monkeys are widely used as experimental primate models. However, only few articles have been published testing toxicological effects of pharmaceuticals on African green monkey. Methods: The present study was carried out with the recompilation of all parameters recorded before the first drug administration in five sub-chronic or chronic toxicological studies performed on 66 Cercopithecus aethiops sabaeus, born in Cuba. Results: This study provides hematological, biochemical, respiratory, cardiovascular and electroneurophysiological data for both choosing animals to be included into experiments and monitoring these parameters during the study. Conclusions: We conclude that this study provides valuable integrated data for determining the health status, including electroneurophysiological parameters, data not previously reported for this species, of the African green monkey.

Original languageEnglish
Pages (from-to)177-186
Number of pages10
JournalJournal of Medical Primatology
Volume39
Issue number3
DOIs
StatePublished - Jun 2010

Keywords

  • Grivet monkeys
  • Old World monkeys
  • Safety studies

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