Hb Monza: A novel extensive HBB duplication with preserved α-β subunit interaction and unstable hemoglobin phenotype

Keyphrases

• Duplication 100%
• Hemoglobin 100%
• Hemoglobin Variant 100%
• Subunit Interaction 100%
• Unstable Hemoglobin 100%
• Thalassemia 66%
• 3D Model 33%
• Molecular Dynamics Simulation 33%
• Histidine Residue 33%
• Hemolytic Crisis 33%
• Thermal Stress 16%
• Functional Interaction 16%
• Structural Change 16%
• Energy Minimization 16%
• Stressful Conditions 16%
• Clinical Phenotype 16%
• Amino Acids 16%
• 3D Modeling 16%
• Production Run 16%
• Protein Destabilization 16%
• Heme 16%
• Root Mean Square Deviation 16%
• Single Amino Acid Substitution 16%
• Generalized Born 16%
• AlphaFold 16%
• Swiss Cheese Model 16%
• Implicit Solvent Model 16%
• Frame Duplication 16%
• Iron Atom 16%
• HBB Gene 16%
• Contact Loss 16%
• Febrile Episode 16%

INIS

• interactions 100%
• phenotype 100%
• hemoglobin 100%
• thalassemia 40%
• chains 30%
• simulation 20%
• molecular dynamics method 20%
• amino acids 20%
• residues 20%
• histidine 20%
• comparative evaluations 10%
• length 10%
• genes 10%
• heating 10%
• iron 10%
• production 10%
• energy 10%
• roots 10%
• thermal stresses 10%
• losses 10%
• instability 10%
• proteins 10%
• modeling 10%
• minimization 10%
• atoms 10%
• solvents 10%
• heme 10%

Biochemistry, Genetics and Molecular Biology

• Hemoglobins 100%
• Histidine 33%
• Wild Type 16%
• Temperature Stress 16%
• Amino Acids 16%
• Hemoglobin Variant 16%
• Amino Acid Substitution 16%