@article{7302f8bd9fb74e91b91e307798be8ded,
title = "Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration",
abstract = "Introduction: Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease. Methods: Surveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis. Results: A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository. Conclusions: The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.",
keywords = "Cerebrovascular disease, Dementia, Magnetic resonance imaging, Radiology, Stroke",
author = "Smith, {Eric E.} and Biessels, {Geert Jan} and {De Guio}, Fran{\c c}ois and {de Leeuw}, {Frank Erik} and Simon Duchesne and Marco D{\"u}ring and Richard Frayne and Ikram, {M. Arfan} and Eric Jouvent and MacIntosh, {Bradley J.} and Thrippleton, {Michael J.} and Vernooij, {Meike W.} and Hieab Adams and Backes, {Walter H.} and Lucia Ballerini and Black, {Sandra E.} and Christopher Chen and Rod Corriveau and Charles DeCarli and Greenberg, {Steven M.} and Gurol, {M. Edip} and Michael Ingrisch and Dominic Job and Lam, {Bonnie Y.K.} and Launer, {Lenore J.} and Jennifer Linn and McCreary, {Cheryl R.} and Mok, {Vincent C.T.} and Leonardo Pantoni and Pike, {G. Bruce} and Joel Ramirez and Reijmer, {Yael D.} and Romero, {Jose Rafael} and Stefan Ropele and Rost, {Natalia S.} and Sachdev, {Perminder S.} and Scott, {Christopher J.M.} and Sudha Seshadri and Mukul Sharma and Steven Sourbron and Steketee, {Rebecca M.E.} and Swartz, {Richard H.} and {van Oostenbrugge}, Robert and {van Osch}, Matthias and {van Rooden}, Sanneke and Anand Viswanathan and David Werring and Martin Dichgans and Wardlaw, {Joanna M.}",
note = "Funding Information: Funding sources: This work was funded by the European Union Joint Program on Neurodegenerative Diseases (EU JPND). The funder had no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. Funding Information: HARNESS was funded by the international Joint Program for Neurodegenerative Diseases initiative to analyze the role of neuroimaging biomarkers in neurodegeneration and dementia. The HARNESS members were invited to participate based on their contributions to cSVD research, including their participation in STRIVE, and to provide a balance of input from different geographic regions and research disciplines. HARNESS included 70 members from 29 institutions in 11 countries, representing disciplines including radiology, biomedical engineering, clinical trials, computer science, epidemiology, medical biophysics, neurology, stroke medicine, and psychiatry. Members were surveyed to identify important needs for harmonizing neuroimaging methods for cSVD and then subdivided into 11 working groups of 6–12 participants representing a range of disciplines, cSVD interests, and location to address these needs. The initiative commenced in July 2016 and culminated in an in-person conference in June 2017. Where appropriate, working groups identified relevant articles through literature searches, expert knowledge, and hand searching articles from reference lists, but formal systematic reviews and creation of evidence tables were considered out of scope. Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = dec,
doi = "10.1016/j.dadm.2019.01.002",
language = "English",
volume = "11",
pages = "191--204",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "John Wiley & Sons Inc.",
}
