ER stress signaling and neurodegeneration: At the intersection between Alzheimer's disease and Prion-related disorders

Mauricio Torres; José Manuel Matamala; Claudia Duran-Aniotz; Victor Hugo Cornejo; Andrew Foley; Claudio Hetz

doi:10.1016/j.virusres.2014.12.018

ER stress signaling and neurodegeneration: At the intersection between Alzheimer's disease and Prion-related disorders

Mauricio Torres, José Manuel Matamala, Claudia Duran-Aniotz, Victor Hugo Cornejo, Andrew Foley, Claudio Hetz

School of Psychology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Alzheimer's and Prion diseases are two neurodegenerative conditions sharing different pathophysiological characteristics. Disease symptoms are associated with the abnormal accumulation of protein aggregates, which are generated by the misfolding and oligomerization of specific proteins. Recent functional studies uncovered a key role of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in the occurrence of synaptic dysfunction and neurodegeneration in Prion-related disorders and Alzheimer's disease. Here we review common pathological features of both diseases, emphasizing the link between amyloid formation, its pathogenesis and alterations in ER proteostasis. The potential benefits of targeting the UPR as a therapeutic strategy is also discussed.

Original language	English
Pages (from-to)	69-75
Number of pages	7
Journal	Virus Research
Volume	207
DOIs	https://doi.org/10.1016/j.virusres.2014.12.018
State	Published - 2 Sep 2015

Keywords

Amyloid formation
ER-stress
Prion-like diseases
Sustained translational repression
Targeting ER-stress
Unfolded protein response (UPR)

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10.1016/j.virusres.2014.12.018

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title = "ER stress signaling and neurodegeneration: At the intersection between Alzheimer's disease and Prion-related disorders",

abstract = "Alzheimer's and Prion diseases are two neurodegenerative conditions sharing different pathophysiological characteristics. Disease symptoms are associated with the abnormal accumulation of protein aggregates, which are generated by the misfolding and oligomerization of specific proteins. Recent functional studies uncovered a key role of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in the occurrence of synaptic dysfunction and neurodegeneration in Prion-related disorders and Alzheimer's disease. Here we review common pathological features of both diseases, emphasizing the link between amyloid formation, its pathogenesis and alterations in ER proteostasis. The potential benefits of targeting the UPR as a therapeutic strategy is also discussed.",

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T2 - At the intersection between Alzheimer's disease and Prion-related disorders

AU - Torres, Mauricio

AU - Matamala, José Manuel

AU - Duran-Aniotz, Claudia

AU - Cornejo, Victor Hugo

AU - Foley, Andrew

AU - Hetz, Claudio

PY - 2015/9/2

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AB - Alzheimer's and Prion diseases are two neurodegenerative conditions sharing different pathophysiological characteristics. Disease symptoms are associated with the abnormal accumulation of protein aggregates, which are generated by the misfolding and oligomerization of specific proteins. Recent functional studies uncovered a key role of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in the occurrence of synaptic dysfunction and neurodegeneration in Prion-related disorders and Alzheimer's disease. Here we review common pathological features of both diseases, emphasizing the link between amyloid formation, its pathogenesis and alterations in ER proteostasis. The potential benefits of targeting the UPR as a therapeutic strategy is also discussed.

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KW - ER-stress

KW - Prion-like diseases

KW - Sustained translational repression

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ER stress signaling and neurodegeneration: At the intersection between Alzheimer's disease and Prion-related disorders

Abstract

Keywords

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