Effects of classic psychedelic drugs on turbulent signatures in brain dynamics

Josephine Cruzat, Yonatan Sanz Perl, Anira Escrichs, Jakub Vohryzek, Christopher Timmermann, Leor Roseman, Andrea I. Luppi, Agustin Ibañez, David Nutt, Robin Carhart-Harris, Enzo Tagliazucchi, Gustavo Deco, Morten L. Kringelbach

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Psychedelic drugs show promise as safe and effective treatments for neuropsychiatric disorders, yet their mechanisms of action are not fully understood. A fundamental hypothesis is that psychedelics work by dose-dependently changing the functional hierarchy of brain dynamics, but it is unclear whether different psychedelics act similarly. Here, we investigated the changes in the brain’s functional hierarchy associated with two different psychedelics (LSD and psilocybin). Using a novel turbulence framework, we were able to determine the vorticity, that is, the local level of synchronization, that allowed us to extend the standard global time-based measure of metastability to become a local-based measure of both space and time. This framework produced detailed signatures of turbulence-based hierarchical change for each psychedelic drug, revealing consistent and discriminate effects on a higher level network, that is, the default mode network. Overall, our findings directly support a prior hypothesis that psychedelics modulate (i.e., “compress”) the functional hierarchy and provide a quantification of these changes for two different psychedelics. Implications for therapeutic applications of psychedelics are discussed.

Original languageEnglish
Pages (from-to)1104-1124
Number of pages21
JournalNetwork Neuroscience
Issue number4
StatePublished - 1 Oct 2022
Externally publishedYes


  • LSD
  • Psilocybin
  • Psychedelics
  • Turbulence


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